Arthritis Rheumatol:1995年至2014年狼疮性肾炎导致终末期肾病的死亡趋势

2018-09-19 xiangting MedSci原创

1995年至2014年间,白人、非洲裔美国人和西班牙裔患者的全因死亡率大幅下降,因心血管疾病和感染导致的死亡风险降低。

美国1995年至2006年间,狼疮性肾炎导致的终末期肾病(LN-ESRD)患者的过早死亡率保持不变。这项研究将分析延长至2014年以发现最新的趋势,并探讨了关键的病因特异性死亡率趋势。

使用全国ESRD患者登记,研究人员确定了1995年1月1日至2014年12月31日患偶发性LN-ESRD的所有患者,按照ESRD的发病年份分为4个五年组(1995-1999、2000-2004、2005-2009、2010-2014)。研究人员评估了每个队列的死亡率。调整协变量后,还分析了全因死亡率和病因特异性死亡率的时间趋势。

确定了1995年至2014年间的20,974名偶发性LN-ESRD患者。每100患者年的死亡率从1995-1999年的11.1(95%CI 10.4-11.8)下降到2010-2014年的6.7(95%CI 6.2-7.2)(p趋势<0.01)。与1995-1999年相比,2010-2014年的调整后死亡率风险比率:白人患者为0.68(95%CI 0.58-0.78),非洲裔美国人为0.67(95%CI 0.57-0.78),西班牙裔为0.51(95%CI为0.38-0.69)。从1995-1999年至2010-2014年,血管疾病(CVD)和感染引起的死亡率分别下降了44%和63%(p趋势均<0.01)。

1995年至2014年间,白人、非洲裔美国人和西班牙裔患者的全因死亡率大幅下降,因血管疾病和感染导致的死亡风险降低。总的来说,这些趋势为改善这一高危人群的治疗提供了重要基准。

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    2018-09-21 zhaojie88
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    2018-09-21 villahu

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