JAMA Pediatr:分娩方式及喂养方式可影响孩子的长期健康

2016-01-12 sunshine MedSci原创

据发表于JAMA Pediatrics的一项新的研究表明,6周龄婴儿的肠道菌群可因其分娩以及喂养方式而受影响。

据发表于JAMA Pediatrics的一项新的研究表明,6周龄婴儿的肠道菌群可因其分娩以及喂养方式而受影响。

“肠道菌群”是指定植于人胃肠道中的多种细菌微生物。自人出生后以及开始饮食后肠道菌群开始出现,而且越来越多的研究表明成年人肠道菌群成分与其健康结果有关。

研究表明,剖宫产与机体日后肥胖、哮喘、腹腔疾病以及1型糖尿病的发生有关;与配方奶粉相比,母乳喂养可降低机体哮喘、肥胖、感染、代谢综合征及糖尿病的发病风险。

目前认为,分娩过程中,婴儿暴露于阴道中的微生物可能与其肠道菌群的成分有关,但是这个影响过程却尚未清楚。

既往小型研究表明,婴儿肠道菌群与其分娩方式以及是否为母乳喂养有关。但是,关于机体的早期暴露与后来肠道菌群的形成以及日后对健康的长期影响却知之甚少。

此外,有证据表明母乳促使婴儿胃肠道系统形成和成熟,或促进有益菌群定植于胃肠道。

阴道分娩及母乳喂养或可促进不同微生物定植

当前研究中,研究人员推测,暴露于母体阴道菌群和/或母乳喂养或可使其后代在形成自身核心微生物时以特定的顺序获得某特定的微生物。这或许是影响机体终身疾病风险的免疫发育差异的关键机制。

Anne G. Hoen博士及其同事探究了(102名)婴儿肠道菌群的组成与其分娩方式及喂养方式之间的关系。

研究人员搜集了关于研究对象分娩方式、喂养方式的数据,并获得其肠道菌群成分的数据。

这些婴儿的平均胎龄为近40周;70名婴儿为阴道分娩和32名为剖宫产。

婴儿出生后最初6周,70名婴儿为母乳喂养,26名母乳和配方奶粉组合喂养,其中6名为完全配方奶粉喂养。

结果表明,肠道菌群的组成与其分娩方式有关。阴道分娩的婴儿和剖宫产的婴儿之间肠道菌群成分的差异与喂养方式所致的差异相当于或略大一些。

完全采用配方奶粉喂养的婴儿与母乳及配方奶粉混合喂养的婴儿在菌群微生物组成上类似。

并没有探究早期喂养方式对菌群影响的长期纵向研究,但是,早期喂养方式似乎可能会对菌群结构产生长期的影响。这些研究发现或可为母乳喂养如何有益于儿童时期及日后的健康提供一个解释。

最后,作者解释道:

“了解健康婴儿肠道菌群的定植模式是确定生命早期特定可变的危险因素及暴露的健康影响的关键。

为此,我们根据婴儿分娩方式及其喂养方式确定了婴儿肠道中菌群成分的差异,以及对婴儿早期及长期健康的可能影响。”

本研究的局限性包括样本量较小以及研究对象来自美国的单一群体。未来研究还可考虑婴儿饮食和时间的确切比例。

原始出处:

Yvette Brazier. Delivery method, infant diet could impact long-term health. MNT, 11 January 2016.

Association of cesarean delivery and formula supplementation with the intestinal microbiome of 6-week-old infants, Juliette C. Madan et al., JAMA Pediatrics, doi:10.1001/jamapediatrics.2015.3732, published online 11 January 2016.

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    2016-04-06 chenchuny

    现在终于为道法自然找到科学依据!

    0

  4. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/14/d0501100fdfe783cab0715811e01c133.jpg, createdBy=51ed1602754, createdName=mengli1984, createdTime=Tue Feb 16 19:53:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59040, encodeId=5a5c5904014, content=自然分娩, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:25:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57423, encodeId=c3a85e4234a, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1664971, encodeId=57f916649e1cc, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sat May 14 10:08:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637252, encodeId=4b8e163e2523f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57424, encodeId=cfef5e424f8, content=继续光柱, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57422, encodeId=7b6d5e42227, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-01-27 feather89
  6. [GetPortalCommentsPageByObjectIdResponse(id=1664971, encodeId=57f916649e1cc, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sat May 14 10:08:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637252, encodeId=4b8e163e2523f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57424, encodeId=cfef5e424f8, content=继续光柱, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57422, encodeId=7b6d5e42227, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-02-16 mengli1984

    还是天然和自然的好

    0

  7. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/14/d0501100fdfe783cab0715811e01c133.jpg, createdBy=51ed1602754, createdName=mengli1984, createdTime=Tue Feb 16 19:53:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59040, encodeId=5a5c5904014, content=自然分娩, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:25:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57423, encodeId=c3a85e4234a, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-01-24 1de3b290m83(暂无匿称)

    自然分娩

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1664971, encodeId=57f916649e1cc, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sat May 14 10:08:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637252, encodeId=4b8e163e2523f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 17 12:08:00 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76094, encodeId=12a1e609491, content=现在终于为道法自然找到科学依据!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=014e108570, createdName=chenchuny, createdTime=Wed Apr 06 19:40:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693883, encodeId=98601693883d7, content=<a href='/topic/show?id=9e633154e6b' target=_blank style='color:#2F92EE;'>#分娩方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31547, encryptionId=9e633154e6b, topicName=分娩方式)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/14/d0501100fdfe783cab0715811e01c133.jpg, createdBy=51ed1602754, createdName=mengli1984, createdTime=Tue Feb 16 19:53:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59040, encodeId=5a5c5904014, content=自然分娩, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:25:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57423, encodeId=c3a85e4234a, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57424, encodeId=cfef5e424f8, content=继续光柱, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57422, encodeId=7b6d5e42227, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-01-14 Lynee劲飞扬

    赞一个

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1664971, encodeId=57f916649e1cc, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sat May 14 10:08:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637252, encodeId=4b8e163e2523f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/14/d0501100fdfe783cab0715811e01c133.jpg, createdBy=51ed1602754, createdName=mengli1984, createdTime=Tue Feb 16 19:53:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59040, encodeId=5a5c5904014, content=自然分娩, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:25:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57423, encodeId=c3a85e4234a, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57424, encodeId=cfef5e424f8, content=继续光柱, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:41:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57422, encodeId=7b6d5e42227, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-01-14 Lynee劲飞扬

    继续光柱

    0

  10. 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG569619FEB03536446.jpg, createdBy=85f81678980, createdName=Lynee劲飞扬, createdTime=Thu Jan 14 13:40:00 CST 2016, time=2016-01-14, status=1, ipAttribution=)]
    2016-01-14 Lynee劲飞扬

    0

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