Dig Liver Dis: 非酒精性脂肪性肝病与非肥胖女性的乳腺癌发生有关

2019-07-07 不详 MedSci原创

越来越多的证据支持非酒精性脂肪性肝病(NAFLD)与肝外癌症发生有关。非酒精性脂肪性肝病(NAFLD)和乳腺癌具有相似的危险因素。因此,本项研究旨在探究NAFLD与乳腺癌之间的关系。

背景
越来越多的证据支持非酒精性脂肪性肝病(NAFLD)与肝外癌症发生有关。非酒精性脂肪性肝病(NAFLD)和乳腺癌具有相似的危险因素。因此,本项研究旨在探究NAFLD与乳腺癌之间的关系。

方法
研究人员将患有非酒精性脂肪性肝病患者与同时接受健康检查的乳腺癌患者一起进行队列对照研究,对所有患者进行乳房X光检查和肝脏超声检查。对相关结果进行进行条件logistic回归分析。

结果
在270名乳腺癌患者和270名对照中,81名癌症患者(30.0%)和54名对照(20.0%)患有NAFLD(P= 0.008)。在多变量分析中,NAFLD与乳腺癌显着相关(P=0.046)。当检查肥胖(BMI≥25kg/ m 2)与乳腺癌患者的NAFLD 之间的相互作用时,注意到肥胖与乳腺癌中NAFLD之间的显着效应修正(P= 0.021)。亚组分析显示NAFLD与非肥胖亚组乳腺癌显着相关(优势比3.04,95%置信区间1.37-4.32,P= 0.002)。

结论
NAFLD在非肥胖的女性患者中与乳腺癌显着相关,是乳腺癌发生的危险因素。

原始出处:

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    2019-08-15 qjddjq
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