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Science：浙大揭维持女性生育力新机制

2013-12-26 驻地记者陈茂樑 通讯员周 炜 医学论坛网

生育能力CRL4蛋白质复合体
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健康的卵子是维持女性生育能力的必要条件。浙江大学生命科学研究院范衡宇教授课题组的最新研究结果发现：一种称为CRL4的蛋白质复合体，对维持卵子的活性至关重要。该研究从分子机制上揭示了维持雌性生育能力、延缓女性更年期的新机制，为了解卵巢早衰、妊娠失败等女性不孕不育疾病的病因提供了全新的认识。相关研究成果的论文已发表在12月20日最新出版的美国《科学》杂志上。 在《科学》杂志上新发表的论文，是浙江大学

健康的卵子是维持女性生育能力的必要条件。浙江大学生命科学研究院范衡宇教授课题组的最新研究结果发现：一种称为CRL4的蛋白质复合体，对维持卵子的活性至关重要。该研究从分子机制上揭示了维持雌性生育能力、延缓女性更年期的新机制，为了解卵巢早衰、妊娠失败等女性不孕不育疾病的病因提供了全新的认识。相关研究成果的论文已发表在12月20日最新出版的美国《科学》杂志上。

在《科学》杂志上新发表的论文，是浙江大学生命科学研究院范衡宇教授实验室与中国科学院动物研究所孙青原研究员实验室合作的关于“雌性生育力维持调节机制”研究的最新成果。

据该课题组专家介绍，在雌性哺乳动物和人类体内，卵母细胞(卵子的前身)和其他细胞相比，其发育过程显得非常特别。女婴出生时，体内有近10万枚左右卵母细胞，它们像一颗颗未萌发的种子一样，处于发育的静止状态。在进入青春期以后，其中的一部分卵母细胞会陆续被激活和长大，在性激素的影响下，发育成熟并最终排卵。以人类为例，通常女性一生可以排卵300～400枚。如果卵子耗竭，就意味着女性将进入更年期。如果在40岁以前发生卵子提前耗竭，临床上称作卵巢早衰。目前，卵巢早衰影响人群中1%～2%的女性。但多年以来，人们对维持卵子存活的分子机制还不是十分清楚。

范衡宇教授课题组的研究人员最初发现，CRL4蛋白质复合体在小鼠卵子中含量特别丰富。这一发现提示，CRL4蛋白质复合体可能在卵子中具有重要功能。接着，课题组在动物实验中，研究人员利用基因敲除技术，阻止了小鼠卵子中CRL4蛋白质复合体的生成，实验研究结果显示，这些小鼠表面上看起来非常健康，却完全失去了生育能力。它们的卵母细胞在出生之后很快就凋亡了，并出现了与人类卵巢早衰相类似的症状。这些卵子即使受精以后，也不能发育成正常胚胎，导致了早期流产。

课题组一系列的实验结果证实，CRL4蛋白质复合体不但能维持卵子的存活，也是受精以后早期胚胎的发育所必需的。经过进一步的生化研究，揭示了CRL4蛋白质复合体从中发挥效用的机制，它能调节卵子中一个催化DNA去甲基化的酶TET，从而保证卵子受精以后发育胚胎，使胚胎基因组的正确重编程，从而使胎儿正常发育。

原文出处：

Chao Yu, Yin-Li Zhang, Wei-Wei Pan, Xiao-Meng Li, Zhong-Wei Wang, Zhao-Jia Ge, Jian-Jie Zhou, Yong Cang, Chao Tong, Qing-Yuan Sun, and Heng-Yu Fan.CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins.Science 20 December 2013: 1518-1521. [DOI:10.1126/science.1244587]


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    2016-04-21 明崖

    不孕不育有了新的期望

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    2013-12-28 jichang

    #SCIE#

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    2013-12-28 ms3323097325231039

    #生育力#

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    2013-12-28 pandamao2014

    #浙大#

    0