Br J Dermatol:酒精摄入量与非黑素瘤皮肤癌的风险相关(Meta分析)

2017-07-31 xiaoxiao MedSci原创

皮肤癌主要包括鳞状细胞癌、基底细胞癌、Bowen病、Paget病、恶性黑色素瘤五大类,以前两者为最多见。在美国,皮肤癌是最常见的癌症,而在我国,皮肤癌发病率较低,对治疗方法的探讨及认识相应较西方发达国家落后。近年来,随着皮肤癌发病率的上升,对该类疾病早期诊断和及时采取有效的的措施进行治疗越来越受到学术界的重视。非黑素瘤性皮肤癌(Nonmelanoma skin cancer,NMSC)主要包括基底

皮肤癌主要包括鳞状细胞癌、基底细胞癌、Bowen病、Paget病、恶性黑色素瘤五大类,以前两者为最多见。在美国,皮肤癌是最常见的癌症,而在我国,皮肤癌发病率较低,对治疗方法的探讨及认识相应较西方发达国家落后。近年来,随着皮肤癌发病率的上升,对该类疾病早期诊断和及时采取有效的的措施进行治疗越来越受到学术界的重视。

非黑素瘤皮肤癌(Nonmelanoma skin cancer,NMSC)主要包括基底细胞癌(BCC)和皮肤鳞状细胞癌(cSCC)。酒精摄入与NMSC的关系一直没有定论;因此,本研究的目的是使用荟萃分析量化酒精的摄入量和NMSC之间的关系。

研究人员系统地检索了2016年10月30日之前PubMed和EMBASE上的文献。涉及饮酒与BCC或cSCC的病例对照研究或队列研究被纳入该研究,且这些研究报告了相对风险(RR)和95%可信区间(CI)。研究共确定了307篇文章,13个病例对照研究和队列研究,共包括95241例 NMSC患者(91942例基底细胞癌患者和3299例鳞癌患者)。通过随机效应模型获得剂量效应荟萃分析的RR和95%CI。

研究人员发现,每天酒精摄入每增加10克,与BCC(RR:1.07; 95% CI:1.04-1.09)和CSCC(RR:1.11;95% CI 1.06-1.16)均呈正相关。虽然有证据表明酒精摄入的增加与BCC之间非线性相关,但这可能是由于酒精摄入量较高的数据较零散所致。该荟萃分析还发现,饮酒与BCC和cSCC的风险以剂量依赖的方式显著相关。

但是该分析中,存在潜在的混杂因素(如个体差异等),因此需要判断性地看待该研究的分析结果。然而,为了降低非黑素瘤皮肤癌的全球健康负担,饮酒这种普遍行为可以作为一个重要的公共健康目标。

原始出处:

Yen H, Dhana A,et al.Alcohol intake and risk of nonmelanoma skin cancer: a systematic review and dose-response meta-analysis.Br J Dermatol. 2017 Jul 26. doi: 10.1111/bjd.15647. [Epub ahead of print]

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    2017-12-20 guojianrong
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    2018-03-06 一闲
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    2017-08-19 lmm397
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    2017-08-04 laoli

    谢谢分享,学习了!

    0

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    2017-08-01 changjiu

    学习了,谢谢

    0

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