Gastroenterol Res Pract:降钙素原能指导腹膜炎术后的抗生素治疗吗?

2017-07-25 MedSci MedSci原创

对于呼吸道感染的患者来说,血清降钙素原是指导抗生素治疗持续时间的有效生化学标志物。本研究的目的是确定PCT水平是否能为腹膜炎患者术后抗生素治疗提供指导。

对于呼吸道感染的患者来说,血清降钙素原是指导抗生素治疗持续时间的有效生化学标志物。本研究的目的是确定PCT水平是否能为腹膜炎患者术后抗生素治疗提供指导。

对腹膜炎术后患者进行随机分组。对照组根据指南在规定期限内接受抗生素治疗。在研究组中,根据血清PCT水平决定是否停止抗生素治疗。患者分为三类:(1)胃肠穿孔、(2)穿孔性阑尾炎、(3)术后并发症。主要研究结果为抗生素持续使用时间。

162名患者被纳入研究,对照组和研究组分别有83名和79名患者。在胃肠道穿孔腹膜炎患者亚组中,PCT指导组抗生素使用时间持续7天,对照组为10天(P=0.065)。在感染并发症、死亡率、住院天数和再次使用抗生素治疗等方面无明显差异。

由此我们可以得出结论:是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。

原始出处:

Slieker JC1, Aellen S2, et al. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterol Res Pract. 2017;2017:3457614. doi: 10.1155/2017/3457614. Epub 2017 May 16.

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    2018-05-13 许安
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226561, encodeId=340f226561e0, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Wed Jul 26 16:39:13 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226328, encodeId=0e3b226328d6, content=是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  5. 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  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226561, encodeId=340f226561e0, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Wed Jul 26 16:39:13 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226328, encodeId=0e3b226328d6, content=是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226561, encodeId=340f226561e0, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Wed Jul 26 16:39:13 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226328, encodeId=0e3b226328d6, content=是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-07-27 xuyong530
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    2017-07-26 137****9095

    henhao

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Jul 26 05:44:58 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226242, encodeId=2daf226242fa, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Jul 25 18:46:05 CST 2017, time=2017-07-25, status=1, ipAttribution=)]
    2017-07-26 有备才能无患

    是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226561, encodeId=340f226561e0, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Wed Jul 26 16:39:13 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226328, encodeId=0e3b226328d6, content=是否在PCT指导下抗生素,对抗生素使用总时间无显著差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-07-25 131****1460

    学习了受益匪浅。

    0

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