Eur Urol:肾细胞肿瘤患者中肠道细菌组成驱使了癌症免疫治疗的原发抗性

2020-05-20 AlexYang MedSci原创

免疫检查点阻断(ICB)的发展革命性的改变了肾细胞肿瘤(RCC)的临床结果。尽管如此,治疗响应的持续时间以及预测的改善仍旧没有满足医疗需求。虽然人们已经认识到抗生素(ATBs)在各种恶心肿瘤中能够减少

免疫检查点阻断(ICB)的发展革命性的改变了肾细胞肿瘤(RCC)的临床结果。尽管如此,治疗响应的持续时间以及预测的改善仍旧没有满足医疗需求。虽然人们已经认识到抗生素(ATBs)在各种恶心肿瘤中能够减少ICB的临床效果,而关于不同肠道非致病菌(共生菌)对ICB治疗RCC结果的之间影响仍旧所知甚少。

最近,有研究人员在晚期RCC患者群体中评估了粪便细菌组成对ICB治疗效果的预测价值情况。研究人员前瞻性的收集了69名晚期RCC患者的粪便样本,并分析了来自健康志愿者(HVs)的2994个样本。另外,研究人员还进行了预临床研究,即将来自对ICB(NR-FMT)具有抗性的RCC患者粪便移植(FMT)到RCC小鼠中来确定肠道细菌组成与ICB临床效果之间的因果关系。研究发现,近期使用ATB(n=11;16%)能够减少客观响应比例(从28%减少到9%,p<0.03),并明显的影响肠道细菌组成,从而促使不同优势性类群的形成,比如Clostridium hathewayi,该类细菌在RCC患者的粪便中与HVs相比也具有优势性。重要的是,在nivolumab之间进行酪氨酸激酶抑制剂(TKIs)治疗能够改变微生物的组成。为了建立肠道细菌组成与ICB效果之间的因果关系,NR-FMT小鼠在进行了FMT或者有益共生菌处理后均表现出了补偿效应。

最后,研究人员指出,TKIs和ATBs能够影响微生物的组成和免疫治疗的成败。进一步的研究将突出这些特异性细菌的作用以及作为新生物标记的潜力。

原始出处:

Lisa Derosa , Bertrand Routy , Marine Fidelle et al. Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients. Eur Urol. 03 May 2020

 

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    2020-06-25 yige2012
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    2020-05-20 Ahui

    不错哦

    0

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    2020-05-20 趴窝的飞机

    1

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