Neurology:急性脑炎转归的预测因素

2015-01-08 高晓方 译 医学论坛网

美国一项研究表明,高龄、免疫受损、昏迷、机械通气和急性血小板减少为急性脑炎的不良预后因素,脑炎病因、癫痫进展、局灶性神经功能缺损和磁共振(MRI)影像学检查所现则与临床转归无关。论文12月24日在线发表于《神经病学》(Neurology)杂志。 此项回顾性研究共纳入198例被诊断为急性脑炎的患者(男性50.5%,中位年龄58岁),并基于最终诊断将患者分为病毒性脑炎、自身免疫性脑炎和其他/

美国一项研究表明,高龄、免疫受损、昏迷、机械通气和急性血小板减少为急性脑炎的不良预后因素,脑炎病因、癫痫进展、局灶性神经功能缺损和磁共振(MRI)影像学检查所现则与临床转归无关。论文12月24日在线发表于《神经病学》(Neurology)杂志。

此项回顾性研究共纳入198例被诊断为急性脑炎的患者(男性50.5%,中位年龄58岁),并基于最终诊断将患者分为病毒性脑炎、自身免疫性脑炎和其他/未知病因脑炎三组。利用多变量Logistic回归分析评估出院时良好或不佳转归的相关性因素,并确定转归预测因子。

结果显示,病毒性、自身免疫性和其他/未知病因脑炎患者分别占48%、22%和30%。出院时转归良好的病毒性、自身免疫性和其他/未知病因脑炎患者分别为50.5%、40.5%和54.2%。上述三组患者的死亡率分别为8%、12%和5%。

多变量回归分析显示,与转归不佳相关的因素为年龄在65岁及以上、免疫受损状态、昏迷、机械通气和急性血小板减少。在病毒性脑炎中,CSF多形核细胞计数亦与转归不佳显著相关。

原始出处:

Tarun D. Singh, Jennifer E. Fugate and Alejandro A. Rabinstein.The spectrum of acute encephalitis Causes, management, and predictors of outcome.Neurology 


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