Eur Respir J:24h动态血压监测对接受CPAP治疗的OSA患者有何价值?

2017-10-20 xing.T MedSci原创

该研究的结果表明,夜间高血压、血压昼夜模式和夜间心率可能是CPAP治疗血压反应的预测因子,这些结果支持对OSA患者在CPAP治疗开始前进行24小时动态血压监测。

连续气道正压通气(CPAP)降低血压的效果中等并且是高度可变的。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究析文章,在这项研究中,研究人员旨在确定对CPAP治疗有血压反应的预测变量。

研究人员对阻塞性睡眠呼吸暂停(OSA)在接受CPAP治疗6个月前后测量了患者24小时动态血压监测(ABPM)、C-反应蛋白(CRP)、瘦素、脂联素和24小时尿儿茶酚胺含量。

该研究共纳入了88名患者重度OSA(平均呼吸暂停低通气指数为42次每小时)的肥胖男性;28.4%的患者有高血压。62例患者完成了研究,研究人员对60例患者进行分析。CPAP治疗后白天舒张压(-2mmHg)和去甲肾上腺素(-109.5nmol/天)均有所降低,但24小时血压、夜间血压、多巴胺、肾上腺素、CRP、血清瘦素和脂联素水平没有明显变化。接受CPAP治疗后,夜间血压正常与和夜间血压升高相关(+4mmHg),而夜间高血压与降低的24小时血压相关(-3mmHg)。多元线性回归模型显示CPAP治疗后夜间血压差异显著。具体来说,夜间心率低(<68bpm)以及勺型血压与升高的夜间BP和新诊断的夜间高血压相关。

该研究的结果表明,夜间高血压、血压昼夜模式和夜间心率可能是CPAP治疗血压反应的预测因子,这些结果支持对OSA患者在CPAP治疗开始前进行24小时动态血压监测。

原始出处:

Anabel L. Castro-Grattoni,et al. Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring. Eur Respir J.2017. http://erj.ersjournals.com/content/50/4/1700651

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    2017-10-22 bioon3
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    2017-10-20 有备才能无患

    连续气道正压通气(CPAP)降低血压的效果中等并且是高度可变的

    0

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    2017-10-20 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0