ANN RHEUM DIS: 18F-FDG-PET/CT在鉴定原因不明发热(FUO)和原因不明炎症(IUO)病因中的作用

2017-09-20 xiangting MedSci原创

18F-氟脱氧葡萄糖正电子发射断层扫描有助于一半以上的FUO和IUO病例确定正确的诊断。

原因不明发热(FUO)和原因不明炎症(IUO)在诊断时具有挑战性。潜在疾病的诊断可能通过18F-氟脱氧葡萄糖正电子发射断层扫描(18F-FDG-PET)得到改善。

这是一项前瞻性研究,测试了18F-FDG-PET/CT在大型FUO或IUO患者队列中的诊断效用,并定义增加18F-FDG-PET/CT 诊断可能性的参数。FUO或IUO患者除了进行标准的诊断处理外还接受18F-FDG-PET/CT扫描。18F-FDG-PET/CT结果被分为对建立最终诊断有帮助或无帮助。使用二元logistic回归识别与诊断性18F-FDG-PET/CT 相关的临床参数。

共240例患者入组,72例为FUO,142例为IUO,26例此前患FUO或IUO(exFUO / IUO)。190例患者明确了诊断(79.2%)。FUO组最主要的诊断为成人发作型Still病(15.3%),IUO组为大血管血管炎(21.1%)和风湿性多肌痛(18.3%)exFUO/IUO组为IgG4相关性疾病(15.4%)。在136例患者中(所有患者的56.7%,明确诊断患者的71.6%),18F-FDG-PET/CT是阳性的有助于诊断。诊断性18F-FDG-PET/CT的预测标志物是年龄超过50岁(p = 0.019),C反应蛋白(CRP)水平超过30mg/L(p = 0.002)和无发热(p = 0.001)。

18F-FDG-PET/CT扫描有助于一半以上的FUO和IUO病例确定正确的诊断。没有间歇发热、年龄较大和CRP水平升高增加诊断性18F-FDG-PET/CT 的可能性。

原始出处:

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    2017-09-30 xugumin
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    2018-05-12 kcb069
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    2017-12-03 feather89
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    2017-09-20 金戈铁马

    不错

    0