Nature:脑部免疫记忆影响小鼠神经疾病进展

2018-04-21 佚名 生物360

根据 4 月 11 日《自然》在线发表 的一篇论文,小鼠身体的免疫应答通过免疫记忆影响小鼠生命后期脑疾病的严重性。

根据 4 月 11 日《自然》在线发表 的一篇论文,小鼠身体的免疫应答通过免疫记忆影响小鼠生命后期脑疾病的严重性。

先天免疫系统可以保留长达数月的感染 “记忆”,从而改变之后的免疫应答。免疫记忆存在两种形式:一是训练,通过训练增强抵抗再感染的免疫应答;二是耐受,持续的暴露会抑制免疫应答。虽然已知体内炎症可以激发脑部免疫应答,但是免疫记忆是否发生在大脑固有免疫细胞——小神经胶质细胞内仍不为人知。调控小神经胶质细胞应答的可能性引起了人们的广泛兴趣,因为这些细胞关乎阿尔茨海默病和中风等疾病。此外,它们极其长寿,因此即使不是永久性的,持久性的修饰也是有可能的。

德国神经退行性疾病研究中心的 Jonas Neher 及同事将脂多糖注入阿尔茨海默病模型小鼠体内,发现小鼠脑部的β- 淀粉样蛋白显着增加。β- 淀粉样蛋白斑激活小神经胶质细胞,据信该细胞会摄入并处理掉β- 淀粉样蛋白。注射一次脂多糖后,小神经胶质细胞似乎产生了训练反应。6 个月后,接受注射的小鼠比未接受注射的对照小鼠积累了更多的β- 淀粉样蛋白。但是,注射四次后就产生了免疫耐受,β- 淀粉样蛋白减少。类似的,作者发现免疫耐受减少了中风后的神经元损伤。研究这些过程或能找到可以缓解神经疾病的新方法。

原始出处:Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani,et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature.11 April 2018

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    2018-08-10 liye789132251
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    2018-04-24 半夏微凉

    学习了谢谢分享

    0

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    2018-04-24 329523732

    不错

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1907697, encodeId=4b2d190e69753, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Thu Sep 27 17:45:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882980, encodeId=9deb18829803a, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Aug 10 07:45:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308743, encodeId=438a308e43f1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Apr 24 07:00:16 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308667, encodeId=519d30866e46, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Apr 24 00:23:46 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613964, encodeId=bea0161396465, content=<a href='/topic/show?id=f587e438580' target=_blank style='color:#2F92EE;'>#神经疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74385, encryptionId=f587e438580, topicName=神经疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 23 14:45:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308217, encodeId=b02130821ef2, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Apr 22 12:11:01 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308117, encodeId=659b30811e2c, content=学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sun Apr 22 07:02:50 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308038, encodeId=f7a2308038ef, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sun Apr 22 00:23:30 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-22 执着追梦

    学习.谢谢分享

    0

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    2018-04-22 周周人

    学习.

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    2018-04-22 神功盖世

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