Blood:II型糖尿病患者更易患血癌?!

2012-06-09 田磊磊 :生物谷

       近日,来自米利亚姆医院的研究者运用一种新的综合分析技术分析表明,II型糖尿病病人存在20%患血癌的风险,如非霍奇金淋巴瘤、白血病和骨髓瘤。这项研究刊登在了Blood杂志上,研究数据为糖尿病和特定类型的癌症之间的联系提供了证据。        研究者Jorge Castill

       近日,来自米利亚姆医院的研究者运用一种新的综合分析技术分析表明,II型糖尿病病人存在20%患血癌的风险,如非霍奇金淋巴瘤、白血病和骨髓瘤。这项研究刊登在了Blood杂志上,研究数据为糖尿病和特定类型的癌症之间的联系提供了证据。
       研究者Jorge Castillo表示,大多数人只认为心脏疾病、肾衰竭和糖尿病直接相关,然而在超过1900万被诊断患有糖尿病的美国人中患血癌等风险比例提高了20%。以前的研究表明,糖尿病和肝癌、胰腺癌有关系,很少有研究揭示血癌和糖尿病之间的关系。

       研究者分析了26篇科学家发表的关于II型糖尿病和淋巴瘤、白血病关系的相关研究论文,而后研究者又对时间范围内超过17000名II型糖尿病患者和血癌患者进行整合分析。最后总结道,II型糖尿病患者患白血病、骨髓瘤以及非霍奇金淋巴瘤的风险明显增加,更有意思的是,研究者发现患淋巴瘤、骨髓瘤以及白血病的患者会因地区不同,其发病风险也不尽相同,如非霍奇金淋巴瘤在亚洲和欧洲比较高发,而白血病在美国和亚洲比较高发。

       研究并没有发现为什么II型糖尿病为什么和这些疾病相关,研究者表示,他们后期还会进行一些深入研究来解释II型糖尿病和血癌之间的潜在关系。Castillo后期会重点研究肥胖、物理活动、抽烟相关的行为因素,这些都和糖尿病、癌症有一定的关系。相关研究由国立卫生研究院提供资助。
文献标题:Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies(全文下载)
文献来源:Blood. 2012 May 24;119(21):4845-50.
PMID:22496152

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