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Int J Nanomed：透明质酸官能化氧化铋纳米颗粒有助于肿瘤的靶向放疗

2017-09-02 MedSci MedSci原创

纳米颗粒放疗
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临床上由于肿瘤的内在抗性及不准确定位使得其放疗的有效性大大降低，为了克服这些局限性，研究人员使用一锅法合成了透明质酸官能化氧化铋纳米颗粒（HA-Bi2O3 NPs）以用于肿瘤的特异性靶向计算机断层扫描（CT）成像和放射治疗。经透明质酸修饰后，Bi2O3 NPs具有良好的水溶性和良好的生物相容性，且经肿瘤细胞摄取后可过度表达CD44受体。所制备HA-Bi2O3 NPs表现较高的X射线衰减效率高和理想

临床上由于肿瘤的内在抗性及不准确定位使得其放疗的有效性大大降低，为了克服这些局限性，研究人员使用一锅法合成了透明质酸官能化氧化铋纳米颗粒（HA-Bi2O3 NPs）以用于肿瘤的特异性靶向计算机断层扫描（CT）成像和放射治疗。

经透明质酸修饰后，Bi2O3 NPs具有良好的水溶性和良好的生物相容性，且经肿瘤细胞摄取后可过度表达CD44受体。所制备HA-Bi2O3 NPs表现较高的X射线衰减效率高和理想的放射增敏可诱导细胞凋亡，并阻滞细胞周期，且以剂量依赖的方式。值得注意的是，这些特性为主动靶向CT成像和增强肿瘤抑制放射敏感性方面提供了优异的性能。

总之，这些研究结果表明，HA-Bi2O3 NPs或可在肿瘤的诊断及治疗过程中作为CT成像诱导放疗的有力助手。

原始出处：

Sameh Samir Ali, Reda Morsy, et al., Synthesized zinc peroxide nanoparticles (ZnO2-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds. Int J Nanomedicine. 2017; 12: 6059–6073. Published online 2017 Aug 21. doi: 10.2147/IJN.S141201.

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    2017-09-05 Jackie Li

    学习

    0

  2. 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    2017-09-05 游手好闲

    学习了

    0

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    2017-09-04 kalseyzl

    #透明质酸#

    0

  4. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 ms3117646317107274

    #纳米颗粒#

    0

  5. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 ms3994565386320060

    #Med#

    0

  6. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 Y—xianghai

    学习了新知识

    0

  7. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 刘煜

    学习了谢谢分享

    0

  8. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 李东泽

    很好.学习了.很有帮助.

    0

  9. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 忠诚向上

    好好看下.内容丰富

    0

  10. 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level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Sep 03 08:30:39 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239950, encodeId=65dc239950df, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 03 07:34:36 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239939, encodeId=2f7d239939b8, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 03 07:25:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239922, encodeId=09be2399220a, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Sep 03 07:02:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239902, encodeId=706e23990202, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Sep 03 06:46:49 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 189****1577

    值得推荐一下

    0

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在一项新的概念验证研究中，来自美国弗雷德-哈金森癌症研究中心和华盛顿大学的研究人员开发出生物可降解的纳米颗粒，这些纳米颗粒能够被用来对T细胞（一种免疫细胞）进行基因编程，使得它们识别和摧毁癌细胞，并且它们仍然停留在体内。 在这项于2017年4月17日在线发表在Nature Nanotechnology期刊上的研究中，这些研究人员证实

Small：光声成像和光热治疗，基于共轭低聚体纳米颗粒的新型光声造影剂和光热材料

近年来，乳腺癌的发病率呈现逐年上升的趋势，引起了人们的广泛关注。其中乳腺癌的淋巴转移是导致患者死亡的主要因素。前哨淋巴结是癌细胞发生淋巴结转移和扩散所必经的第一站，因此前哨淋巴结活检术已经被广泛应用于乳腺外科领域。该技术可以通过切除和活检前哨淋巴结，来判断病理的阳性或阴性，并确定是否采取腋窝淋巴结清扫。而准确探测和定位前哨淋巴结是实施前哨淋巴结活检术的前提条件。目前，最常见的检测示踪方法包括亚甲基

Adv Sci：新型siRNA纳米颗粒有效地逆转了肝损伤

RNA干扰（RNAi）作为后基因组时代的一种下调基因表达的工具已被广泛用于基因功能的研究以及疾病的治疗。近年来随着RNA干扰技术在生命领域的应用以及研究的深入，RNA干扰成为了生命科学领域的一个研究热点。小干扰RNA (siRNA)介导的RNA干扰正是通过下调致病基因从而对很多人类疾病实现治疗，如癌症、自身免疫性疾病以及病毒感染性疾病等。但由于siRNA自身的局限性（细胞内不稳定性、肾清除率高、细

基于铁氧化物的纳米颗粒，肿瘤特异性释放单线态氧

活性氧（ROS）诱导的细胞凋亡已广泛应用于癌症的治疗。尽管光动力治疗（PDT）受益于活性氧生成的空间 - 时间控制，但其对光、光敏剂和氧气的精细匹配需求极大地阻碍了 PDT 作为癌症治疗选择的首选。美国国立卫生研究院的陈小元教授课题组与厦门大学的聂立铭教授课题组合作，开发了一种基于铁氧化物的肿瘤特异性酸性 pH 可控释放单线态氧的纳米颗粒。酸性条件下，铁氧化物颗粒（IO-LAHP）释放的铁

Nat Nanotechnol：开发出新的抗癌纳米颗粒，有望长期阻止癌症复发

在一项新的研究中，来自美国梅约诊所等研究机构的研究人员开发出一种新的旨在让乳腺瘤萎缩同时阻止其复发的抗癌纳米颗粒。接受这种纳米颗粒注射的小鼠的肿瘤大小下降了70～80%。最令人关注的是，接受这种纳米颗粒治疗的小鼠抵抗未来的肿瘤复发，即便在治疗一个月后接触到癌细胞，也是如此。相关研究结果于2017年5月1日在线发表在Nature Nanotechn