J Gastroenterology: 胃癌ABC分型中的A型患者血清蛋白酶异常时应进行上消化内镜检查

2018-09-08 MedSci MedSci原创

ABC分型已被用于常规评估胃癌的风险情况。ABC分型中A型是指当前患有或过去得过幽门螺杆菌的患者。这项研究的目的是评估A型患者当前以及过去感染幽门螺杆菌的比例,并尝试建立一个标准,用于鉴定尿素呼气试验(UBT)和/或粪便抗原阴性结果的A型患者胃癌的发生。

背景
ABC分型已被用于常规评估癌的风险情况。ABC分型中A型是指当前患有或过去得过幽门螺杆菌的患者。这项研究的目的是评估A型患者当前以及过去感染幽门螺杆菌的比例,并尝试建立一个标准,用于鉴定尿素呼气试验(UBT)和/或粪便抗原阴性结果的A型患者癌的发生。

方法
ABC分型中获得A型分型的201名患者接受了UBT和/或粪便抗原测试,以及上消化道内窥镜检查。根据内窥镜检查结果确定的幽门螺杆菌感染状况并对受试者进行分类。在组之间比较胃蛋白酶原(PG)I,PG II和PG I / II比率,并构建接受者操作特征曲线并计算截断值。

结果
通过UBT和/或粪便抗原测试,22名患者拥有阳性结果。研究人员对剩余的179名患者中的157名患者进行了的内窥镜图像分析。15名受试者被认为患有幽门螺杆菌感染。用于测定过去幽门螺杆菌感染的PG I和PG I / II比的最佳截止值分别≤31.2ng/ mL和≤4.6。

结论
大约20%的A型患者患有(过)幽门螺杆菌感染。增加UBT和/或粪便抗原测试可以识别当前感染,但不能检测以前的感染。血清PG水平可用于鉴定之前患有过幽门螺杆菌感染的患者。

原始出处:

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    2018-09-28 许安
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