J Clin Periodontol:牙周治疗可以调节糖尿病患者内皮组细胞的基因表达

2017-09-18 lishiting MedSci原创

牙周炎与II型糖尿病(T2DM)以及内皮功能障碍密切相关。这篇研究的目的是为了检测牙周治疗对糖尿病患者内皮祖细胞(EPCs)免疫炎症基因表达的影响。

牙周炎与II型糖尿病(T2DM)以及内皮功能障碍密切相关。这篇研究的目的是为了检测牙周治疗对糖尿病患者内皮祖细胞(EPCs)免疫炎症基因表达的影响。

研究将18名罹患T2DM以及中等至重度慢性牙周炎的患者随机分配至2组:治疗组:口腔卫生指导(OHI)+刮治和根面清创(n=11);对照组:仅OHI (n=7)。在治疗前和术后6个月提取外周血样本以备生化检验以及EPCs培养。从治疗组中随机抽取4名患者的EPCs,第一次通过基于PCR阵列的分析检测84个Toll-like受体信号相关基因的表达变化。随后,2组中基因表达差异再通过qPCR进行验证。

结果显示,治疗组中所有受试者的牙周状况均得到显著改善。在84个测试基因中,IL-6和IL-8的转录在治疗后明显下调超过2倍,并且这种现象在2组所有受试者中均得到qPCR的进一步验证(p<0.05)。

这项初步研究表明:通过对IL-6和IL-8转录的检测显示,牙周治疗可以显著减少EPCs中免疫炎症基因的表达。

原始出处

Wang Y, Liu HN, et al. Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients. J Clin Periodontol. 2017 Aug 23. doi: 10.1111/jcpe.12806.

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    2018-08-16 feather89
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    2017-09-20 131****2916

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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Sep 18 23:03:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-19 tanxingdoctor

    学习啦!谢谢分享!

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Sep 18 23:03:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-19 cherry bomb

    学习了谢谢分享

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Sep 18 23:03:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-19 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Sep 18 23:03:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-18 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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研究表明,II型糖尿病(T2DM)与牙周炎密切相关。这篇研究的目的是为了检测日本老龄人群口腔就诊情况与糖尿病之间的联系。

J Periodontol:牙周治疗的微生物学反应以及临床疗效的多变量预测

这篇研究的目的是为了评估2阶段的抗菌牙周疗法的微生物学反应,并测试相关微生物、临床和生物标记物变化以寻求临床治疗成功的预后指标。

J Clin Periodontol:广泛侵袭性牙周炎的牙齿丧失:牙周支持治疗17年后的预后因素

目的:这项回顾性纵向研究评估了大学中广泛性侵袭性牙周炎(GAgP)患者牙周治疗后牙齿脱落的风险和预后因素。

J Periodontal Res:吸烟对牙周治疗后炎症,龈沟液中骨重塑标记物和龈下微生物的影响

牙周通过抑制微生物介导的局部炎性宿主反应维持健康。吸烟可能会影响这一过程。本研究比较了慢性牙周炎患者治疗期和支持性牙周治疗后,重度吸烟者和非吸烟者的骨改建标志物和龈沟液含量。

Intern Med:牙周治疗能降低心血管疾病的发生率

牙周病患者更容易患心血管疾病(CVD)。糖尿病,尤其是严重牙周炎患者,会增加CVD的死亡风险。然而,牙周治疗的结果会因不同的治疗方式而异。本研究旨在探究牙周治疗是否会影响2型糖尿病和牙周炎患者的CVD发生。采用回顾性队列研究设计,数据来自台湾国民健康保险公布的数据集(NHI)。该数据集由随机抽样的新诊断的糖尿病患者组成,他们从1999年到2001年获得保险津贴;年龄小于18岁或1999年以前已经患

J Periodontol:非手术治疗可以有效减少LAP中Aa的JP2克隆表型

之前的研究已经表明,放线菌总核细胞(Aa)以及其白细胞高致毒性的JP2基因型与局限性侵袭性牙周炎(LAP)密切相关。这篇研究的目的是为了评估LAP个体在牙周治疗后是否存在JP2。