Heart:二尖瓣脱垂与心源性猝死

2018-09-23 xing.T MedSci原创

由此可见,尽管SCD的人群流行率低,但不明原因SCD受害者中MVP的高患病率提供了MVP与SCD相关的间接证据。尽管一般MVP人群中危及生命的心律失常事件的发生率仍然很低,但暴露于SCD风险的个体绝对数量仍是显著的。高风险特征包括双叶脱垂、心室纤维化、ST-T波异常和频繁复杂的心室异位。

二尖瓣脱垂(MVP)通常被认为是良性疾病。然而,有研究表明它可能与心源性猝死(SCD)有关。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员进行了一项荟萃分析和系统评价,旨在明确:(1)普通人群中MVP的患病率; (2)所有SCD和原因不明的SCD受害者中MVP的患病率; (3)MVP患者中SCD的发生率和(4)SCD的危险因素。

研究人员检索了英语医学文献:查找了报道(1)MVP患者社区患病率; (2)SCD受害者队列中MVP的患病率; (3)MVP患者SCD发生率和(4)MVP患者SCD的危险因素等文献。最终,研究人员确定了34项研究。本研究已在PROSPERO中心注册(CRD42018089502)。

社区人群中MVP的患病率为1.2%(95%CI为0.5-2.0)。在SCD受害者中,死因仍未确定的人数占22.1%(95%CI为13.4至30.7); 其中,观察到MVP占11.7%(95%CI为5.8至19.1)。MVP患者人群中SCD的发病率为每年0.14%(95%CI为0.1-0.3)。SCD的潜在危险因素包括双叶脱垂、心室纤维化复杂心室异位和ST-T波异常。

由此可见,尽管SCD的人群流行率低,但不明原因SCD受害者中MVP的高患病率提供了MVP与SCD相关的间接证据。尽管一般MVP人群中危及生命的心律失常事件的发生率仍然很低,但暴露于SCD风险的个体绝对数量仍是显著的。高风险特征包括双叶脱垂、心室纤维化、ST-T波异常和频繁复杂的心室异位。

原始出处:


Chrishan J Nalliah.et al. Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis.Heart. 2018. http://dx.doi.org/10.1136/heartjnl-2017-312932

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    2018-09-25 zhaojie88
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    2018-09-25 wwzzly
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    2018-09-25 slcumt
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    2018-09-25 mhm295

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