PLOS Biology:科学家首次确定安慰剂发挥作用的脑区

2016-10-30 MedSci MedSci原创

来自西北医学院和芝加哥康复研究所(RIC)的科学家们首次发现了在大脑中负责缓解疼痛“安慰剂效应”的区域,该研究结果已发表于PLOS Biology。  确定止痛安慰剂效应的最佳效应点或为1亿患有慢性疼痛的美国人提供更加个性化的治疗方案。功能磁共振成像技术的出现或带来了一个个性化的疼痛治疗的时代,基于大脑对药物的反应原理使用靶向疼痛药物。通过消除患者在试验前的高安慰剂反应,这一发现也将带来

来自西北医学院和芝加哥康复研究所(RIC)的科学家们首次发现了在大脑中负责缓解疼痛“安慰剂效应”的区域,该研究结果已发表于PLOS Biology。 

确定止痛安慰剂效应的最佳效应点或为1亿患有慢性疼痛的美国人提供更加个性化的治疗方案。功能磁共振成像技术的出现或带来了一个个性化的疼痛治疗的时代,基于大脑对药物的反应原理使用靶向疼痛药物。

通过消除患者在试验前的高安慰剂反应,这一发现也将带来更精确和准确的疼痛药物的临床试验。

研究人员在一次试验中发现了该脑区,且重复试验显示成功率为95%。

目前,实验设置研究中安慰剂反应主要是在健康受试者中应用。虽然这样的实验有助于理解实验中安慰剂反应的生物学和行为学基础,但是并不能很好的转化应用于诊所中,而那里的患者疼痛主要是慢性疼痛。

此研究中,科学家首次利用功能性磁共振成像结合一个标准的临床试验设计,得到一个无偏差的基于脑神经的标记物来预测安慰剂治疗慢性膝关节骨性关节炎患者效果。结果显示,服用安慰剂具有很强的镇痛效果,50%以上的患者报告有显著的疼痛缓解。

原始出处:

Placebo sweet spot for pain relief identified in brain. Science Daily, October 28, 2016.

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  1. 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    2020-06-30 唐宋

    好文章

    0

  2. 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    2017-07-28 sunylz
  3. 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  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4eqPnIpM089Qsbgj1tic153Nwobjgc4QQVnA4OQpPlV88lyyoyTNgdqkfzuPzSiamf3uv9Gl29OvOQ/0, createdBy=18da1932527, createdName=破阵子, createdTime=Mon Oct 31 08:45:50 CST 2016, time=2016-10-31, status=1, ipAttribution=)]
    2016-11-01 保守主义

    又学到新东西了

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4eqPnIpM089Qsbgj1tic153Nwobjgc4QQVnA4OQpPlV88lyyoyTNgdqkfzuPzSiamf3uv9Gl29OvOQ/0, createdBy=18da1932527, createdName=破阵子, createdTime=Mon Oct 31 08:45:50 CST 2016, time=2016-10-31, status=1, ipAttribution=)]
    2016-11-01 thlabcde

    好东西学习了!

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4eqPnIpM089Qsbgj1tic153Nwobjgc4QQVnA4OQpPlV88lyyoyTNgdqkfzuPzSiamf3uv9Gl29OvOQ/0, createdBy=18da1932527, createdName=破阵子, createdTime=Mon Oct 31 08:45:50 CST 2016, time=2016-10-31, status=1, ipAttribution=)]
    2016-11-01 wxl882001

    好资料,知道学习

    0

  7. 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  8. 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    2016-10-31 明月清辉

    厉害,学习了

    0

  9. 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    2016-10-31 半夏微凉

    学习了,继续关注!

    0

  10. 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    2016-10-31 破阵子

    太棒了

    0

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