Diabetes Care:1型糖尿病患者低血糖和心血管事件、死亡风险研究

2016-07-22 Mechront 译 MedSci原创

根据一项以人群为基础的队列研究的数据,在过去一年中发生严重低血糖事件的1型糖尿病患者,死亡或心血管疾病的风险增加。来自台湾成功大学医学院的Chin-Li Lu博士进行了两项巢式病例对照研究,纳入10411名1型糖尿病患者,探究低血糖对全因死亡率和心血管疾病风险的影响。数据包括了564个死亡者和匹配的1615例对照组。当然还有发生主要心血管事件(n = 743)和没有发生这些事件的对照组(n = 1

根据一项以人群为基础的队列研究的数据,在过去一年中发生严重低血糖事件的1型糖尿病患者,死亡或心血管疾病的风险增加。

来自台湾成功大学医学院的Chin-Li Lu博士进行了两项巢式病例对照研究,纳入10411名1型糖尿病患者,探究低血糖对全因死亡率和心血管疾病风险的影响。数据包括了564个死亡者和匹配的1615例对照组。当然还有发生主要心血管事件(n = 743)和没有发生这些事件的对照组(n = 1439)。

数据显示,在过去的一年里有严重低血糖事件的患者,死亡几率增加了2.74倍(95% CI, 1.96-3.85);出现心血管事件的可能性增加了2.02倍(95% CI, 1.35-3.01)。在过去1至3年或3到5年发生低血糖事件也与更高的全因死亡率有关 (OR = 1.94; 95% CI, 1.39-2.71和OR = 1.68; 95% CI, 1.15-2.44)。

在那些死亡的患者中,研究人员确定了三个主要原因:44.8%死于糖尿病,16.4%死于恶性肿瘤,12.4%死于循环系统疾病。死者也倾向于更多的生活在农村地区,并有更低的收入为基础的保险费。

研究人员写道:“患者和临床工作者应适当管理1型糖尿病,防止严重低血糖的发生。如果发生了低血糖事件,应该告诉患者接下来的全因死亡率或心血管事件的可能风险。”

原始出处:

Lu CL, et al. A Population-Based Study of All-Cause Mortality and Cardiovascular Disease in Association With Prior History of Hypoglycemia Among Patients With Type 1 Diabetes.Diabetes Care. 2016;doi:10.2337/dc15-2418.

Hypoglycemia linked to CVD, mortality in type 1 diabetes.
Healio.July 20, 2016

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  5. 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  6. 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target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon May 01 08:13:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95374, encodeId=72ac953e445, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Mon Aug 01 09:50:00 CST 2016, time=2016-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255578, encodeId=5dd212555e807, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jul 24 14:13:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  7. 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encodeId=5dd212555e807, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jul 24 14:13:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    低血糖的发生同样可怕,所以不能过犹不及,矫枉过正,要制定个体化的降糖目标

    0

  8. 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  9. 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encodeId=5dd212555e807, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jul 24 14:13:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-08-01 青荷

    学习了,继续关注

    0

  10. 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