Arthritis Rheumatol:炎性肠病和急性前葡萄膜炎与中轴型SpA的病程相关

2018-05-18 xiangting MedSci原创

AxSpA患者出现急性前葡萄膜炎或炎性肠病的风险随病程而升高,而银屑病与AxSpA的病程不相关。

这项研究在两个大型、独立、全国范围的AxSpA队列中确定了关节外表现(EAMs)与基线患者特征之间的关联,并定义其潜在差异预后价值,其中这两个队列的招募时间不同。

所分析的数据来源于(Be-)Giant队列,该队列纳入2010年以来的连续性AxSpA患者,而ASPECT包括2004年2月至2005年间强直性脊柱炎(AS)连续性患者和疑似AS患者的信息。

在1250名比利时AxSpA患者中,只有急性前葡萄膜炎和炎性肠病与疾病病程相关,每10年病程风险分别升高20%(RR 1.2,p<0.001)和30%(RR 1.3,p=0.026)。对171名新诊断的患者亚组进行前瞻性随访,发现与无EAMs或单纯银屑病患者相比,AAU或IBD患者随时间变化的CRP平均水平较高(p=0.01)。

AxSpA患者出现急性前葡萄膜炎或炎性肠病的风险随病程而升高,而银屑病与AxSpA的病程不相关,这似乎与更高的累积炎症暴露有关,也可能解释了不同的结构性进展。

原始出处:

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    2019-01-24 gostraight
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    2018-05-23 hippocratez

    非常有意思的研究

    0

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    2018-05-23 hippocratez

    有意思

    0

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    2018-05-20 zhaojie88
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    2018-05-19 changjiu

    学习一下谢谢

    0