2016（第四届）非编码RNA研讨会

2016-09-18 MedSci MedSci原创

非编码RNA是指不能翻译为蛋白的功能性RNA分子,占人类基因组的98%，之前被认为是没有功能的---大多数事实上也被转录为RNA。这些大量的非编码RNA在人类生物学和疾病中发挥的作用如今是一个获得广泛研究的领域。其中常见的具调控作用的非编码RNA包括小干涉RNA、miRNA、piRNA以及长链非编码RNA。近年来大量研究表明非编码RNA在表观遗传学的调控中扮演了越来越重要的角色。 miRNA是一

非编码RNA是指不能翻译为蛋白的功能性RNA分子,占人类基因组的98%，之前被认为是没有功能的---大多数事实上也被转录为RNA。这些大量的非编码RNA在人类生物学和疾病中发挥的作用如今是一个获得广泛研究的领域。其中常见的具调控作用的非编码RNA包括小干涉RNA、miRNA、piRNA以及长链非编码RNA。近年来大量研究表明非编码RNA在表观遗传学的调控中扮演了越来越重要的角色。

miRNA是一类大小在22个核苷酸左右的小分子非编码RNA，主要通过碱基互补配对抑制靶mRNA的翻译或诱导其降解，在转录后水平负调控基因表达，广泛参与细胞的分化，增殖，凋亡，个体生长发育以及器官形成等生物学过程。miRNA家族包含大批癌性基因或抑癌基因，而且在血液中以非常稳定的形式存在，它们的异常表达可以作为肿瘤临床诊断、分类、分级甚至预后与治疗的指标。此外miRNA 在精子发育调控、免疫调控和造血细胞分化里发挥重要作用。

长链非编码RNA(lncRNA)是长度大于200 bp，不编码蛋白质的内源性RNA分子。近年来的研究表明，lncRNA可以作为一种竞争性内源RNA(competing endogenous RNA，ceRNA)吸附miRNA，参与靶基因的表达调控，从而在肿瘤的发生发展中发挥重要的作用。最近几年来的研究表明lncRNAs通常与重要蛋白质因子形成RNA-蛋白质复合体以发挥其生物学功能，包括细胞核亚结构的形成、基因表达的遗传与表观遗传调控等。

piRNA (PIWI-interacting RNA)是继miRNA之后、于2006年7月发现的一类动物生殖细胞特异性小分子非编码RNA，其大小在26-32核苷酸之间。目前认为，piRNA途径可能是动物生殖细胞进化获得的一个独特的对抗外来入侵遗传元件、维持自身基因组稳定和完整的作用通路，推测piRNA可能在表观遗传水平和转录后水平沉默转座子、逆转座子等DNA移动元件，但目前对piRNA的功能机制还了解不多。

本届生物谷主办的2016非编码RNA 研讨会将围绕非编码RNA调控机理，技术进展及疾病调控邀请国内外知名专家学者座谈，展示最新非编码RNA研究成果，为大家带来一次沉默世界的非编码RNA奇妙之旅。

召开时间：2016.10.28 －10.29 大会语言：中文
会议地点：上海

非编码RNA的起源与进化

microRNA微流体芯片

非编码RNA在癌症发生中的功能和机制

非编码RNA疾病数据库

实时定量PCR(qRT-PCR)的miRNA检测技术

非编码RNA与精子发育调控

非编码RNA生物信息学分析高通量RNA-array检测

miRNA与造血干细胞的发育和分化

非编码RNA与表观遗传调控基因表达谱功能分析

非编码RNA与免疫调控

非编码RNA与细胞分化及发育

与蛋白质相互作用 (RNA pull-down，RIP，nRIP)

miRNA与肥胖及糖尿病

非编码RNA与干细胞重编程

与DNA相互作用((ChRIP，ChOP，CHART)

lncRNA与心血管系统疾病

非编码RNA结构预测研究

高通量分析(ChIRP-Seq，SHAPE-Seq，FragSeq，HITS-CLIP/CLIP-Seq)

非编码RNA与神经退行性疾病

microRNA海绵调控

非编码RNA生物标志物

非编码RNA(circRNA，ceRNA，piRNA)调控新机制

非编码RNA相关药物研发

会议官方网址：http://www.bioon.com/z/2016ncrna/

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言

评论区 (5)

#插入话题

插入图片

[GetPortalCommentsPageByObjectIdResponse(id=1994727, encodeId=10e11994e275d, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Dec 02 20:00:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743430, encodeId=ca361e43430ab, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Dec 22 04:00:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584645, encodeId=95981584645af, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Mon Sep 19 15:00:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129154, encodeId=8662129154ea, content=嗯，认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInIuedI6ibt6I6oaCwaHVjGTt4ylhQ5Z3Mzpqw5t0yU9mtuRrLMUyjY3OPtRzDwibcWrZyeDAOqk3g/0, createdBy=f4971930340, createdName=lizedong88, createdTime=Sat Sep 17 09:08:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93746, encodeId=cd5393e4630, content=学习了，科学研究越来越进步和微观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Jul 20 01:35:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
2016-12-02 kcb069

#研讨会#

28 0
[GetPortalCommentsPageByObjectIdResponse(id=1994727, encodeId=10e11994e275d, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Dec 02 20:00:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743430, encodeId=ca361e43430ab, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Dec 22 04:00:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584645, encodeId=95981584645af, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Mon Sep 19 15:00:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129154, encodeId=8662129154ea, content=嗯，认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInIuedI6ibt6I6oaCwaHVjGTt4ylhQ5Z3Mzpqw5t0yU9mtuRrLMUyjY3OPtRzDwibcWrZyeDAOqk3g/0, createdBy=f4971930340, createdName=lizedong88, createdTime=Sat Sep 17 09:08:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93746, encodeId=cd5393e4630, content=学习了，科学研究越来越进步和微观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Jul 20 01:35:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
2016-12-22 d830384

#非编码#

36 0
[GetPortalCommentsPageByObjectIdResponse(id=1994727, encodeId=10e11994e275d, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Dec 02 20:00:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743430, encodeId=ca361e43430ab, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Dec 22 04:00:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584645, encodeId=95981584645af, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Mon Sep 19 15:00:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129154, encodeId=8662129154ea, content=嗯，认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInIuedI6ibt6I6oaCwaHVjGTt4ylhQ5Z3Mzpqw5t0yU9mtuRrLMUyjY3OPtRzDwibcWrZyeDAOqk3g/0, createdBy=f4971930340, createdName=lizedong88, createdTime=Sat Sep 17 09:08:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93746, encodeId=cd5393e4630, content=学习了，科学研究越来越进步和微观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Jul 20 01:35:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
2016-09-19 12498f6em12暂无昵称

#编码#

26 0
[GetPortalCommentsPageByObjectIdResponse(id=1994727, encodeId=10e11994e275d, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Dec 02 20:00:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743430, encodeId=ca361e43430ab, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Dec 22 04:00:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584645, encodeId=95981584645af, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Mon Sep 19 15:00:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129154, encodeId=8662129154ea, content=嗯，认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInIuedI6ibt6I6oaCwaHVjGTt4ylhQ5Z3Mzpqw5t0yU9mtuRrLMUyjY3OPtRzDwibcWrZyeDAOqk3g/0, createdBy=f4971930340, createdName=lizedong88, createdTime=Sat Sep 17 09:08:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93746, encodeId=cd5393e4630, content=学习了，科学研究越来越进步和微观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Jul 20 01:35:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
2016-09-17 lizedong88

嗯，认真学习

71 0
[GetPortalCommentsPageByObjectIdResponse(id=1994727, encodeId=10e11994e275d, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Dec 02 20:00:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743430, encodeId=ca361e43430ab, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Dec 22 04:00:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584645, encodeId=95981584645af, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Mon Sep 19 15:00:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129154, encodeId=8662129154ea, content=嗯，认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInIuedI6ibt6I6oaCwaHVjGTt4ylhQ5Z3Mzpqw5t0yU9mtuRrLMUyjY3OPtRzDwibcWrZyeDAOqk3g/0, createdBy=f4971930340, createdName=lizedong88, createdTime=Sat Sep 17 09:08:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93746, encodeId=cd5393e4630, content=学习了，科学研究越来越进步和微观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Jul 20 01:35:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
2016-07-20 明崖

学习了，科学研究越来越进步和微观

115 0

内科

外科

专科科室

热点

按科室浏览

临床工具

科研工具

其他工具

科研数智化

真实世界研究解决方案

数字化学术传播解决方案

其它

转化医学

2016（第四届）非编码RNA研讨会

相关资讯

科室

工具

服务