AACE 2016:肥胖的2型糖尿病患者,其炎症标志物显著增加

2016-05-29 Seven L MedSci原创

研究结果显示,在2型糖尿病的肥胖患者中,超敏C反应蛋白水平和白细胞计数均增加。肥胖和糖化血红蛋白水平之间未发现相关性。来自沃洛沃大学的David Soyoye博士和同事对155名2型糖尿病患者(平均年龄56.5岁,有66名男性)进行了交叉型研究,评估肥胖、糖化血红蛋白水平和炎症标记物之间的关系。数据显示,男性和女性的平均BMI分别为25.8 kg/m2和29.2 kg/m2;其中BMI>30 kg

研究结果显示,在2型糖尿病的肥胖患者中,超敏C反应蛋白水平和白细胞计数均增加。肥胖和糖化血红蛋白水平之间未发现相关性。

来自沃洛沃大学的David Soyoye博士和同事对155名2型糖尿病患者(平均年龄56.5岁,有66名男性)进行了交叉型研究,评估肥胖、糖化血红蛋白水平和炎症标记物之间的关系。

数据显示,男性和女性的平均BMI分别为25.8 kg/m2和29.2 kg/m2;其中BMI>30 kg/m2的占23.3%。男性和女性的平均腰围分别为93.2 cm和97.5 cm;男性腰围>94 cm、女性腰围>80 cm的占75.8%。男性和女性的平均HbA1c分别为7.99%和7.88%;平均总白细胞计数为5.99 x 103 mm3和5.83 x 103 mm3;平均hs-CRP浓度为1.23 mg/L和1.68 mg/L。

分析显示,腰围与白细胞计数呈正相关(P = .024),BMI与白细胞计数呈正相关(P = .022),BMI与hs-CRP呈正相关(P = .028),但是肥胖与HbA1c无关。

研究表明,肥胖和炎症标志物(总白细胞计数和hs-CRP)之间有显著的相关性。脂肪库不仅作为能量储备,而且会分泌细胞因子和炎症介质,从而刺激肝细胞中的s-CRP的产生。细胞因子也能促进白细胞的活化和产生。炎症已被假定为血管性糖尿病并发症的主要致病途径。

原始出处:

Soyoye D, et al. Abstract #253. Presented at: The American Association for Clinical Endocrinologists Annual Scientific & Clinical Congress; May 25-29, 2016; Orlando, Fla.

Obesity linked with increased inflammatory markers in type 2 diabetes.Healio.May 28, 2016

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    2016-08-25 shanyongle
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    2016-07-21 zgwhgch
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    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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