Int J Impot Res:阴茎勃起功能障碍与嗜中性粒细胞与淋巴细胞比例、血小板与淋巴细胞比例之间的关系研究

2017-12-17 AlexYang MedSci原创

老龄化男性阴茎勃起功能障碍(ED)的最重要的起因为器官机能疾病,主要是由于动脉硬化引起的血管障碍。之前,有研究表明了动脉硬化能够表现出活跃的炎症过程,而不是因为脂质浸润而引起的消极的血管损伤。最近,有研究人员探究了ED与嗜中性粒细胞与淋巴细胞比例(NLR)和血小板与淋巴细胞比例(PLR)之间的关系,NLR和PLR均为炎症标记。在2014年12月到2015年5月之间,101名年龄在40-70岁的且患

老龄化男性阴茎勃起功能障碍(ED)的最重要的起因为器官机能疾病,主要是由于动脉硬化引起的血管障碍。之前,有研究表明了动脉硬化能够表现出活跃的炎症过程,而不是因为脂质浸润而引起的消极的血管损伤。最近,有研究人员探究了ED与嗜中性粒细胞与淋巴细胞比例(NLR)和血小板与淋巴细胞比例(PLR)之间的关系,NLR和PLR均为炎症标记。

在2014年12月到2015年5月之间,101名年龄在40-70岁的且患有ED的男性病人包括在他们的研究中。31名性活跃、没有ED且具有相似的临床和个人背景特征的男性包括在对照组中。研究人员比较了对照组和病人组之间的NLR和PLR值,以及其他激素的、生化的和血液的参数。病人组和对照组的平均年龄分别为49(40-69)和48(43-65)岁。

研究发现,并存病,比如高血压糖尿病、慢性阻塞性肺病(COPD)和冠状动脉疾病在两个小组之间并没有显著的不同(p>0.05)。NLR和PLR值在病人组中要比对照组显著性更高(p<0.05).更多的是,检测到的CRP水平在病人组中要比对照组显著性更高(p<0.001)。在相关性分析中,NLR、PLR和CRP水平与IIEF-5得分呈负相关关系。多变量分析确定了ED的独立预测因子。PLR被鉴定为是ED的独立预测因子。另外,NLR、尤其是PLR与ED的诊断相关,并且这些比例可以作为实用的参数并且不会引起额外的费用。

原始出处:

Murat Sambel, Metin Kilic, Murat Demirbas et al. Relationship between erectile dysfunction and the neutrophil to lymphocyte and platelet to lymphocyte ratios. Int J Impot Res. 01 Dec 2017.

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488222, encodeId=a467148822289, content=<a href='/topic/show?id=91eb9e5483c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97548, encryptionId=91eb9e5483c, topicName=阴茎勃起功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad678405328, createdName=shijzhiewnjhch, createdTime=Tue Dec 19 04:42:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502721, encodeId=b0901502e218d, content=<a href='/topic/show?id=bf0f3342395' target=_blank style='color:#2F92EE;'>#勃起功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33423, encryptionId=bf0f3342395, topicName=勃起功能)], attachment=null, 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    2017-12-19 dingxiaobo
  5. 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  6. 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  7. 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  8. 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