NEJM:Ibalizumab用于多药耐药性HIV感染者效果显著

2018-08-16 zhangfan MedSci原创

研究认为ibalizumab可有效治疗多药耐药性HIV感染

人源化IgG 4单克隆抗体Ibalizumab,可通过与CD4的非竞争性结合,阻断HIV病毒进入T细胞。

在近日的单中心III期临床研究中,研究人员招募了40名多种抗病毒药物耐药的成年HIV感染者,患者HIV-RNA拷贝数1000以上。经7天稳定期后,患者接受2000mg ibalizumab,7天后再次接受病毒拷贝数测试。在为期25天的研究中,患者每2周接受800mg ibalizumab治疗。研究的主要终点是病毒拷贝数降低0.5 log10以上的患者比例。

31人完成研究,平均基线病毒拷贝数4.5 log10,平均CD4计数150。7天后二次测试显示,33人(83%)达到主要终点,平均病毒拷贝数降低1.1 log10。25周时,ibalizumab治疗组平均病毒拷贝数降低1.6 log10,43%的患者其病毒负荷低于50,50%的患者病毒负荷低于200。10名患者治疗失败或复发,体外测试显示9人对ibalizumab敏感性较基线降低。20%患者出现腹泻,是最常见的不良事件。4 名患者死于其他基础疾病,1名患者出现治疗相关的免疫重建炎症综合征。

研究认为ibalizumab可有效治疗多药耐药性HIV感染

原始出处:

Brinda Emu et al. Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1. N Engl J Med.August 16 2018.

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    2018-12-21 snf701207
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    2018-09-15 kafei

    学习了谢谢

    0

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    2018-08-16 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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