BMJ:血糖控制不佳引起的顽固性恶心和呕吐

2016-08-19 MedSci MedSci原创

女性患者,54岁,患有1型糖尿病,出现恶心、早饱、腹痛和间歇性呕吐4年而就诊。近几个月来出现了顽固性的恶心和呕吐,经常需要住院治疗。患者血糖控制很差,青少年时期血糖就已升高,且餐后频繁发生严重低血糖。 患者的糖尿病史已有45年,合并糖尿病视网膜病变,周围神经病变和肾病。同时患者还存在慢性背部疼痛和抑郁症。 用药史包括,就餐时使用15个单位的赖谷胰岛素(速效胰岛素),睡前使用26个单位的

女性患者,54岁,患有1型糖尿病,出现恶心、早饱、腹痛和间歇性呕吐4年而就诊。近几个月来出现了顽固性的恶心和呕吐,经常需要住院治疗。患者血糖控制很差,青少年时期血糖就已升高,且餐后频繁发生严重低血糖

患者的糖尿病史已有45年,合并糖尿病视网膜病变,周围神经病变和肾病。同时患者还存在慢性背部疼痛和抑郁症。

用药史包括,就餐时使用15个单位的赖谷胰岛素(速效胰岛素),睡前使用26个单位的甘精胰岛素(长效胰岛素)。其他使用的药物还包括兰索拉唑、阿托伐他汀、佐匹克隆、加巴喷丁、甲氧氯普胺(短期),硫酸吗啡,和乳果糖。

患者体重为68.6公斤,BMI为28公斤/平方米,血压为129/78 mm Hg,无下降趋势。身上到处可见胰岛素注射针孔,全身体检并未见特别异常的地方。

糖化血红蛋白(HbA1c)为11.6%(103毫摩尔/摩尔),钠133 mmol/L(参考范围133-146),钾4.9 mmol/L(3.5-5.3)、尿素12.3 mmol/L(2.5-7.8),肌酐113µmol/L(60-120),肾小球滤过率为65毫升/分钟/ 1.73平方米(90-120),血糖19.3毫摩尔/升(3.3-6.0)。血红素为145 g/L(115-165),白细胞计数12.1×109/L(4.0-11.0),血小板251×109/L(140-400)。六个月前上消化道内镜检查未发现梗阻或溃疡,但是患者禁食八小时后胃内仍存有残余食物(图1⇓)。腹部超声检查正常。



诊断为糖尿病胃轻瘫。治疗包括静脉补液纠正脱水,使用止吐剂或促进胃动力的药物,并严格控制血糖。

饮食建议(少量多餐,低脂低纤维饮食),促动力药以及优先控制血糖。通过改变降糖药来改善患者的血糖控制情况是非常重要的。

原始出处:

S Gururaj Setty, Marie-France Kong. Intractable nausea and vomiting associated with poor glycaemic control in a patient with type 1 diabetes. BMJ 2016; 354 doi: http://dx.doi.org/10.1136/bmj.i4197

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    2016-09-23 1e10c84am36(暂无匿称)

    文章不错,继续学习

    0

  4. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-14 青龙偃月

    学习了,赞一个!

    0

  5. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-08 lhl629

    学习学习。。。

    0

  6. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  7. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-05 1e0ece0dm09(暂无匿称)

    谢谢指点,学习了

    0

  8. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-12 gaoxiaoe
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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-09-02 1771ae4158m

    学习一下,好

    0

  10. 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content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 16:09:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-08-28 李东泽

    这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

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