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Sci Sig：TGFβ信号为何既促癌又抑癌？新研究揭示部分原因

2016-08-25 佚名 生物谷

TGFβ信号癌症
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科学家们的许多研究工作已经表明肿瘤的生长受到体内细胞分泌的转化生长因子TGFbeta的影响，并且在肿瘤发育的不同阶段TGFbeta发挥着相反的作用：既会抑制肿瘤发育又会刺激肿瘤发育。但是人们对于其中的机制仍了解较少。最近一项发表在国际学术期刊Science Signaling上的新研究揭示了这一过程背后的一些重要细节。 TGFbeta能够调节细胞生长和分化，特别是在胎儿发育阶段。而在肿瘤发育


科学家们的许多研究工作已经表明肿瘤的生长受到体内细胞分泌的转化生长因子TGFbeta的影响，并且在肿瘤发育的不同阶段TGFbeta发挥着相反的作用：既会抑制肿瘤发育又会刺激肿瘤发育。但是人们对于其中的机制仍了解较少。最近一项发表在国际学术期刊Science Signaling上的新研究揭示了这一过程背后的一些重要细节。

TGFbeta能够调节细胞生长和分化，特别是在胎儿发育阶段。而在肿瘤发育的背景下，TGFbeta发挥的作用更加复杂。在肿瘤形成伊始，由于TGFbeta能够抑制细胞分裂并刺激细胞死亡，因此发挥抑制肿瘤形成的作用。而到了肿瘤发育的晚期阶段，TGFbeta会反过来刺激肿瘤细胞增殖和转移，加速肿瘤形成。

乌普萨拉大学的路德维格癌症研究所对TGFbeta信号在肿瘤发育中的机制和作用进行了超过30年的研究。最近这篇文章部分解释了TGFbeta从抑制到增强肿瘤发育这一转换过程的机制。

研究人员发现TGFbeta与癌蛋白Ras共同影响了p53家族的一个成员。众所周知p53蛋白在调节肿瘤发育过程中发挥关键作用，经常在肿瘤中发生突变。该研究发现TGFbeta和Ras能够抑制突变p53蛋白的作用，增强了p53家族另外一种叫做ΔNp63的蛋白的作用，这种蛋白会刺激肿瘤的发育和转移。

“我们希望这些发现能够帮助找到一种特异性方法，抑制TGFbeta信号对肿瘤发育的刺激作用，同时不影响该信号对肿瘤发育的抑制作用，最终可以借助TGFbeta信号对抗癌症。”来自瑞典乌普萨拉大学的研究人员这样说道。

原始出处

Eleftheria Vasilaki1, Masato Morikawa1, Daizo Koinuma2, Anna Mizutani2, Yudai Hirano2,Shogo Ehata2,Anders Sundqvist1, Natsumi Kawasaki2, Jessica Cedervall3, Anna-Karin Olsson3, Hiroyuki Aburatani4,Aristidis Moustakas1,3, Kohei Miyazono1,2,*, and Carl-Henrik Heldin1,*.Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.Sci Sig.2016

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    2017-02-05 changhe722

    #促癌#

    0

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    2017-05-11 jingyanzhu715_39486108

    #抑癌#

    0

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    2017-03-13 yuanming7

    #TGFβ#

    0

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    2017-05-19 changhe713

    #TGF#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1677565, encodeId=82b616e7565e8, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Sun Feb 05 18:55:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640649, encodeId=cee8164064923, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Thu May 11 22:55:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035801, encodeId=7617203580186, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Mar 13 23:55:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035841, encodeId=2e702035841d6, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Fri May 19 12:55:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104362, encodeId=be2c104362e8, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104365, encodeId=58a81043656b, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104369, encodeId=5d33104369ad, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-26 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1677565, encodeId=82b616e7565e8, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Sun Feb 05 18:55:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640649, encodeId=cee8164064923, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Thu May 11 22:55:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035801, encodeId=7617203580186, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Mar 13 23:55:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035841, encodeId=2e702035841d6, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Fri May 19 12:55:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104362, encodeId=be2c104362e8, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104365, encodeId=58a81043656b, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104369, encodeId=5d33104369ad, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-26 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1677565, encodeId=82b616e7565e8, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Sun Feb 05 18:55:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640649, encodeId=cee8164064923, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Thu May 11 22:55:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035801, encodeId=7617203580186, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Mar 13 23:55:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035841, encodeId=2e702035841d6, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Fri May 19 12:55:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104362, encodeId=be2c104362e8, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104365, encodeId=58a81043656b, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104369, encodeId=5d33104369ad, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 26 10:59:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-26 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0