Clin Exp Rheumatol:超重和肥胖影响类风湿性关节炎滑膜炎的临床评估

2018-08-23 xiangting MedSci原创

与超声相比,高BMI类风湿性关节炎患者的SJC和DAS28均被临床评价低估了。

体重指数(BMI)会影响类风湿性关节炎(RA)的预后。由于肥胖相关的过量脂肪组织,肿胀关节计数(SJC)的临床评估也会受到肥胖的影响。这项研究在评估BMI对RA疾病活动性评估影响方面,比较了超声(US)和临床检查。

这是一项单中心研究,纳入RA患者(ACR/EULAR标准)。US评估由一位不知道临床数据并训练有素的风湿病医师完成。US滑膜炎定义为灰度评分≥2和/或能量多普勒评分≥1。主要结局指标是SJC临床和US评估间的差异(ΔSJC)(US-临床检查)。次要结局是评估3个BMI亚组中28关节疾病活动性评分(ΔDAS28)的临床和US评估间的差异,BMI根据WHO标准分类。

纳入76例RA患者(平均年龄53.8±11.8岁;67%女性)。总体而言,分别有28例(36.8%)、33例(43.4%)和15例(19.7%)患者为正常体重、超重和肥胖。3个BMI亚组间的基线特征没有差异。对于超重和肥胖RA患者,US确定的SJC显著高于临床确定的SJC:分别为p=0.001和p=0.049。仅在超重组内US的DAS28高于临床检查(p=0.002)。单因素方差分析(ANOVA)显示3个BMI亚组间的ΔDAS28存在显著差异(p=0.046)。

与超声相比,高BMI类风湿性关节炎患者的SJC和DAS28均被临床评价所低估了。

原始出处:

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    2018-08-25 lmm397
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    2018-08-25 pcw106
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