Gastroenterology:显微结肠炎与炎症性肠病风险

2020-05-19 MedSci原创 MedSci原创

显微结肠炎患者的炎症性肠病风险显著增加

显微镜下结肠炎与炎症性肠病(IBD)有共同的致病机制。近日研究人员利用全国性队列研究的数据,考察了显微结肠炎与IBD事件风险之间的关系。
 
研究人员收集了瑞典1990-2017年间显微镜下结肠炎患者数据,总计包含28个医疗中心的13957名患者,同时招募了一般人群对照(N=66820)和无病兄弟姐妹(N=13943)。
 
截至2017年12月,在显微镜下结肠炎患者中,总计确诊323例溃疡性结肠炎(UC)和108名克罗恩病(CD)病例,而一般人群中,确诊94例UC和42例CD患者。平均显微镜下结肠炎发病到UC确诊的时间为3.2年,CD为3.3年。多因素模型中,显微镜下结肠炎患者的CD风险为12.6,UC风险为17.3,IBD风险为16.8。10年CD绝对的额外风险为0.9,UC为2.6。敏感性分析中,与未受影响的兄弟姐妹相比,显微结肠炎患者CD和UC风险分别为5.4和9.4。
 
研究认为,显微结肠炎患者的炎症性肠病风险显著增加。
 
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