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KIDNEY INT：补充维生素D对CKD患者血管功能的影响！

2017-07-01 xing.T MedSci原创

维生素DCKD血管功能
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由此可见，在非糖尿病性3-4期CKD以及缺乏维生素D的患者中，补充维生素D可以改善其血管功能。

维生素D缺乏与CKD患者的死亡率相关，补充维生素D可能降低CKD患者的心血管疾病风险。近日，肾脏病领域权威杂志kidney international上发表了一篇研究文章，在这项随机、双盲、安慰剂对照试验中，研究人员调查了120例18-70岁的男性和女性非糖尿病性CKD3-4期的维生素D缺乏症（血清25羟维生素D≤20ng/ml）患者补充胆骨化醇对血管功能的影响。研究人员以1:1的比例将患者随机分组，在基线和8周分别接受直接观察的口服剂量的维生素D3（300000 IU）或匹配的安慰剂。该研究的主要结局为16周肱动脉血流介导的内皮依赖性扩张变化。次要结局指标包括脉搏波速度和循环生物标志物的变化。研究人员发现维生素D3补充剂在16周显著增加内皮依赖性肱动脉血流介导的血管扩张，而安慰剂治疗组没有变化（组间平均变化为5.49%；95%可信区间为4.34%到6.64%；P＜0.001）。此外，研究人员发现维生素D3补充干预还导致脉搏波速度和循环IL-6水平发生显著的有利变化。由此可见，在非糖尿病性3-4期CKD以及缺乏维生素D的患者中，补充维生素D可以改善其血管功能。原始出处：Vivek Ku

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    2018-04-19 12498f17m78暂无昵称

    #CKD患者#

    0

  2. 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    2017-07-19 1e1263e3m20(暂无匿称)

    维生素不容小觑

    0

  3. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, 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    2017-07-03 往日如昨

    学习了谢谢分享

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=1603057, encodeId=10b2160305e1d, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Mon Jul 03 07:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217986, encodeId=384521e986e1, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 1249859em41(暂无昵称)

    #血管功能#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1768834, encodeId=8fd71e6883429, content=<a href='/topic/show?id=51cd4e9650' target=_blank style='color:#2F92EE;'>#CKD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4796, encryptionId=51cd4e9650, topicName=CKD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9fa237912269, createdName=12498f17m78暂无昵称, createdTime=Thu Apr 19 09:02:00 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=223995, encodeId=1bbc22399536, content=维生素不容小觑, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Wed Jul 19 21:11:09 CST 2017, time=2017-07-19, status=1, ipAttribution=), 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 gwc389

    #kidney#

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 惠映实验室

    学习了，谢谢

    0

  7. 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createdName=惠映实验室, createdTime=Mon Jul 03 06:54:30 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217929, encodeId=39e621e9297d, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/05/30/99bec6cc787188da3751f87718b3f54e.jpg, createdBy=86442053325, createdName=133****4869, createdTime=Mon Jul 03 03:41:55 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217899, encodeId=2c6b21e8997f, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Jul 02 23:39:35 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 133****4869

    好

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-02 Drhzm308

    学习了，谢谢

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217752, encodeId=dce521e752b5, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 02 10:12:48 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217581, encodeId=fb4c21e58152, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-02 131****1460

    学习了受益匪浅。

    0

  10. 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createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 02 00:32:02 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-02 189****7206

    学习了受益匪浅

    0

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