PLOS ONE:益生菌对孕妇代谢健康的影响

2018-05-23 海北 MedSci原创

最近,来自中国医学科学院,北京协和医学院的研究人员进行了一项荟萃分析,旨在评估补充益生菌对孕妇代谢健康和妊娠并发症的影响。

孕产妇肥胖和妊娠期糖尿病GDM)的患病率正在迅速增加。已有的研究表明,益生菌补充剂可改善人体代谢健康。最近,来自中国医学科学院,北京协和医学院的研究人员进行了一项荟萃分析,旨在评估补充益生菌对孕妇代谢健康和妊娠并发症的影响。

研究人员进行了文献检索,数据提取和质量评估,并根据标准化指南合成数据。该荟萃分析纳入了10项符合条件的随机临床试验。

对于GDM孕妇,研究人员发现补充益生菌和空腹血清胰岛素(OR = 2.94,95CI [-5.69-0.20]p = 0.04),以及胰岛素抵抗的稳态模型评估(HOMA-IR)( OR -0.65,95CI [-1.18-0.11]p = 0.02)之间存在负相关。

GDM患者补充益生菌与血脂水平无显着相关性,包括总胆固醇OR2.72,95CI [-17.18,11.74]P = 0.71),高密度脂蛋白胆固醇HDL-c)(OR-0.29,95CI [-3.60,3.03]P = 0.87),低密度脂蛋白胆固醇(LDL-c)(OR-0.38,95CI [-18.54,17.79]P = 0.97),或甘油三酯( OR -12.83,95CI [-36.63,10.97]P = 0.29)。

对于健康孕妇,益生菌补充剂与空腹血清胰岛素(OR-3.76,95CI-4.29-3.23P <0.00001),以及HOMA-IROR-0.57,95CI-1.08 -0.06]p = 0.03)呈负相关。然而,补充益生菌和空腹血糖(FPG)之间没有显着相关性(OR -2.02,95CI [-5.56,1.52]p = 0.26)。

因此,该研究表明,怀孕期间补充益生菌对葡萄糖代谢有益,但对孕妇脂质代谢没有显著影响。


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    2018-09-28 若轩

    还有怎么补充益生菌呢

    0

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    2018-05-23 龙胆草

    学习谢谢分享

    0

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    2018-05-23 1e17414fm02(暂无匿称)

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