Cell Metabol：特殊激素可逆转肥胖

2015-03-06 佚名生物谷

近日，一篇刊登在国际杂志Cell Metabolism上的一篇研究论文中，来自南加州大学的研究人员通过研究发现，一种新型激素或可帮助抵御因高脂肪西方饮食引发的体重增加，同时也可以促进和锻炼相关的机体代谢效应变得正常。激素是一种机体信号分子，其可以诱发机体多种生理学反应，这种新发现的激素名为MOTS-c，其可以靶向作用肌肉组织，在肌肉组织中其可以恢复胰岛素的敏感性，并且中和饮食诱导和个体年龄依赖

近日，一篇刊登在国际杂志Cell Metabolism上的一篇研究论文中，来自南加州大学的研究人员通过研究发现，一种新型激素或可帮助抵御因高脂肪西方饮食引发的体重增加，同时也可以促进和锻炼相关的机体代谢效应变得正常。

激素是一种机体信号分子，其可以诱发机体多种生理学反应，这种新发现的激素名为MOTS-c，其可以靶向作用肌肉组织，在肌肉组织中其可以恢复胰岛素的敏感性，并且中和饮食诱导和个体年龄依赖的胰岛素耐受性。Pinchas Cohen教授表示，这项研究为我们阐明了在开发年龄相关的疾病的疗法上的一些进步，比如治疗糖尿病等。为了检测MOTS-c引发的机体效应，研究者将其注射入食用高脂肪饮食的小鼠机体中，高脂肪饮食可以促进小鼠机体肥胖并且产生对胰岛素的耐受性；而MOTS-c的注射不仅可以抑制小鼠的肥胖和胰岛素耐受性效应，而且还可以逆转因年龄相关的胰岛素耐受性这种状况往往在糖尿病发病之前发生。

研究者Changhan Lee指出，这项研究也为我们理解线粒体及其作为代谢活性调节子的重要地位提供了很好的依据，MOTS-c是一种特殊的激素，其主要是由线粒体DNA进行编码，而其它激素则由细胞核中的DNA进行编码。

截至目前，所有对MOTS-c进行的研究都是在实验室小鼠机体中进行的，该激素在小鼠机体中发挥功能的分子机制也和其它哺乳动物一样，当然包括人类在内；对MOTS-c的进一步研究已经授权给了一家生物技术公司，随后他们将在三年内开始进行人类临床试验研究。本文研究由美国国立卫生研究院等机构提供资助。

原始出处

Changhan Lee1, , , Jennifer Zeng1, Brian G. Drew2, Tamer Sallam4, Alejandro Martin-Montalvo3, Junxiang Wan1, Su-Jeong Kim1, Hemal Mehta1, Andrea L. Hevener2, Rafael de Cabo3, Pinchas Cohen1.The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabol.2014

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2015-05-06 一闲

#MET#

28 0
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2015-10-11 hlycom3356

感谢作者分享

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2015-06-11 ljjj1053

好好学习一下

108 0
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2015-12-29 guojianrong

#Meta#

38 0
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2015-05-11 zhaozhouchifen

#Cell#

24 0
[GetPortalCommentsPageByObjectIdResponse(id=1895788, encodeId=1a6d1895e8823, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed May 06 18:45:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38411, encodeId=436d3841186, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:22:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27136, encodeId=85e42e13607, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Thu Jun 11 18:52:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887429, encodeId=2057188e42995, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Dec 29 12:45:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869038, encodeId=df5218690380c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 11 05:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959289, encodeId=d7f91959289fd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Sep 26 22:45:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18140, encodeId=026a18140e5, content=MOTS-c中文怎么翻译？, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160714/IMG5786F4E4B293A5717.jpg, createdBy=92b21616283, createdName=fantasticer, createdTime=Thu Mar 12 09:00:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597927, encodeId=643d159e927e3, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Sun Mar 08 00:45:00 CST 2015, time=2015-03-08, status=1, ipAttribution=)]
2015-09-26 维他命

#CEL#

23 0
[GetPortalCommentsPageByObjectIdResponse(id=1895788, encodeId=1a6d1895e8823, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed May 06 18:45:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38411, encodeId=436d3841186, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:22:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27136, encodeId=85e42e13607, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Thu Jun 11 18:52:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887429, encodeId=2057188e42995, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Dec 29 12:45:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869038, encodeId=df5218690380c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 11 05:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959289, encodeId=d7f91959289fd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Sep 26 22:45:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18140, encodeId=026a18140e5, content=MOTS-c中文怎么翻译？, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160714/IMG5786F4E4B293A5717.jpg, createdBy=92b21616283, createdName=fantasticer, createdTime=Thu Mar 12 09:00:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597927, encodeId=643d159e927e3, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Sun Mar 08 00:45:00 CST 2015, time=2015-03-08, status=1, ipAttribution=)]
2015-03-12 fantasticer

MOTS-c中文怎么翻译？

86 0
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2015-03-08 闆锋旦

#ABO#

21 0

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