我国首次完成寨卡病毒全基因组序列测定

2016-02-25 彭科峰 沈基飞 中国科学报

从军事医学科学院获悉,该院与广州市第八人民医院、出入境检验检疫系统相关单位密切合作,在获得从委内瑞拉归国患者临床标本后,采用高通量测序技术,于2月21日直接从尿液中获得病毒全基因组序列。 寨卡病毒属黄病毒科,是一种主要由伊蚊传播的虫媒病毒。1947年首次在乌干达寨卡丛林中的恒河猴体内分离出该病毒,全长基因组序列在2007年被测出。感染寨卡病毒的人群中通常仅有20%的人发病,潜伏期为3至12天。

从军事医学科学院获悉,该院与广州市第八人民医院、出入境检验检疫系统相关单位密切合作,在获得从委内瑞拉归国患者临床标本后,采用高通量测序技术,于2月21日直接从尿液中获得病毒全基因组序列。

寨卡病毒属黄病毒科,是一种主要由伊蚊传播的虫媒病毒。1947年首次在乌干达寨卡丛林中的恒河猴体内分离出该病毒,全长基因组序列在2007年被测出。感染寨卡病毒的人群中通常仅有20%的人发病,潜伏期为3至12天。

专家介绍,这是我国首次获得寨卡病毒全基因组序列,也是全球首次直接从患者尿液中获得病毒全基因组。该病毒基因组全长10.8kb,系统进化分析表明,属于亚洲世系,与巴西、苏里南、波多黎各等美洲国家流行毒株同源性为99.7%,核苷酸序列比对发现20个突变位点,其中5个突变位点导致氨基酸改变。寨卡病毒全基因组序列的获得,为病毒的溯源和进化提供了重要证据,可用于指导诊断试剂、疫苗和药物的研发,使我国在疫情防控中占得先机。

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    2016-02-25 sillywu

    值得庆祝一下~:~

    0

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    2016-02-25 medcardio

    有钱就是好

    0

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