Hepatology:门脉血栓患者食管胃静脉曲张出血研究

2016-05-21 Seven L MedSci原创

食管胃底静脉曲张破裂出血常见于无肝硬化的门静脉血栓形成患者。肝硬化食管静脉曲张破裂出血的进展与肝硬化食管静脉曲张的发展相似。研究人员对来自巴塞罗那、西班牙、巴黎、法国的326名无肝硬化的慢性门静脉血栓(PVT)患者进行了研究,最终178名患者的数据纳入了分析,中位数随访49个月。15%的患者(n = 27)以食管静脉曲张破裂出血为首要表现,对其他患者的最初内窥镜检查显示34%的患者(n = 52)

食管胃底静脉曲张破裂出血常见于无肝硬化的门静脉血栓形成患者。肝硬化食管静脉曲张破裂出血的进展与肝硬化食管静脉曲张的发展相似。研究人员对来自巴塞罗那、西班牙、巴黎、法国的326名无肝硬化的慢性门静脉血栓(PVT)患者进行了研究,最终178名患者的数据纳入了分析,中位数随访49个月。

15%的患者(n = 27)以食管静脉曲张破裂出血为首要表现,对其他患者的最初内窥镜检查显示34%的患者(n = 52)没有静脉曲张,19%的患者(n = 28)有小的食管静脉曲张,40%的患者(LEV; n = 60)有大的食管静脉曲张,7%的患者(n = 11)胃底静脉曲张,没有LEVs。

分析表明,腹水和脾大是存在静脉曲张的独立预测因素。没有静脉曲张的患者其1年内发展为静脉曲张的可能性为2%,3年内为22%,5年内为22%。

在那些小的食管静脉曲张患者中,1年、3年和5年发展为LEVs的可能性分别为13%、40%和54%。一级预防的LEVs患者在第1年、3年和5年发生食管静脉曲张破裂出血的可能性分别为9%、20%和32%。

中位数51个月的时间里有5%的患者死亡,只有一个病人的死亡是由于食管静脉曲张破裂出血。1年、3年和5年的生存期分别为99%、98%和96%。单变量Cox回归分析显示,年龄、肝脏酶学的改变和基线存在腹水和死亡率相关。

研究结果表明,慢性肝硬化静脉曲张的过程,非PVT似乎类似于肝硬化;采用与肝硬化相同的治疗方法可低出血风险和死亡。

原始出处:

Ferreira CN, et al. Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis
.Hepatology. 2016;doi:10.1002/hep.28466.

Gastroesophageal variceal bleeding common in patients with PVT.Healio.May 20, 2016

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    2017-02-28 fusion
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    2016-05-23 gwc384
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    2016-05-23 zhouqu_8
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