Eur Respir J:产妇分娩年龄、肺功能和子代哮喘!

2018-06-09 xing.T MedSci原创

由此可见,孕妇年龄与成人肺功能增强和较少的哮喘/症状有关。与孕妇年龄相关的后代的生物学特性需要进一步研究。

关于母亲年龄对后代呼吸健康的潜在影响的信息十分有限。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员分析了分娩时母亲年龄与成年子女肺功能、呼吸系统症状和哮喘的关系,以及根据后代性别存在的潜在差异。

来自欧洲共同体呼吸健康调查(ECRHs)II研究的13个国家的10692名成年人对标准化访谈进行了回应,并提供了25至55岁时的肺功能测量结果和血清IgE测量结果。在Logistic和线性多层次混合模型中,研究人员调整了参与者的特征(年龄、教育、中心、老年兄弟姐妹的数量)和母亲特征(吸烟、怀孕),同时调查性别差异的影响。使用挪威出生登记处的数据,在亚样本中验证了产妇年龄。

增加的孕产妇年龄与增加的1秒用力呼气量(每年2.33毫升,95%可信区间为0.34 - 4.32)相关,并且在女性中更加一致(趋势P=0.025),相比于男性(趋势P=0.14)。哮喘(比值比为0.85,95%可信区间为0.79-0.92)和呼吸症状(比值比为0.87,95%可信区间为0.82-0.92)随着产妇年龄(每增加5岁)的增加而降低,但在男性中不显著(分别有相互作用P=0.05和0.001)。在各个中心这些结果,并没有解释混杂因素。

由此可见,孕妇年龄与成人肺功能增强和较少的哮喘/症状有关。与孕妇年龄相关的后代的生物学特性需要进一步研究。

原始出处:


Francisco Gómez Real,et al. Maternal age at delivery, lung function and asthma in offspring: a population-based survey. Eur Respir J. 2018. http://erj.ersjournals.com/content/51/6/1601611

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    2018-06-13 楚钟
  2. [GetPortalCommentsPageByObjectIdResponse(id=1736260, encodeId=73e81e36260f6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Wed Jun 13 11:37:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324380, encodeId=b6c5324380f4, content=很好很好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Fri Jun 15 09:20:27 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275146, encodeId=4aed12e514682, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Mon Jun 11 01:37:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323159, encodeId=ccde3231592b, content=优质资料.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jun 11 00:28:10 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322788, encodeId=e4e9322e88c7, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jun 09 11:19:51 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-15 phoebeyan520

    很好很好.学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1736260, encodeId=73e81e36260f6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Wed Jun 13 11:37:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324380, encodeId=b6c5324380f4, content=很好很好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Fri Jun 15 09:20:27 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275146, encodeId=4aed12e514682, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Mon Jun 11 01:37:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323159, encodeId=ccde3231592b, content=优质资料.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jun 11 00:28:10 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322788, encodeId=e4e9322e88c7, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jun 09 11:19:51 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-11 linlin2312
  4. [GetPortalCommentsPageByObjectIdResponse(id=1736260, encodeId=73e81e36260f6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Wed Jun 13 11:37:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324380, encodeId=b6c5324380f4, content=很好很好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Fri Jun 15 09:20:27 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275146, encodeId=4aed12e514682, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Mon Jun 11 01:37:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323159, encodeId=ccde3231592b, content=优质资料.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jun 11 00:28:10 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322788, encodeId=e4e9322e88c7, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jun 09 11:19:51 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-11 phoebeyan520

    优质资料.值得学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1736260, encodeId=73e81e36260f6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Wed Jun 13 11:37:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324380, encodeId=b6c5324380f4, content=很好很好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Fri Jun 15 09:20:27 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275146, encodeId=4aed12e514682, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Mon Jun 11 01:37:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323159, encodeId=ccde3231592b, content=优质资料.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jun 11 00:28:10 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322788, encodeId=e4e9322e88c7, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jun 09 11:19:51 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-09 大爰

    学习了谢谢分享!!

    0