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Am J Cardiol：延长置入DES患者双抗治疗增出血风险

2014-05-16 寒林 译 中国医学论坛报手机报

DES患者双抗治疗出血风险
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一项荟萃分析表明，与短期治疗相比，置入药物洗脱支架(DES)患者延长双联抗血小板治疗(DAPT)与大出血事件增加相关，但与复合终点发生率(死亡或心肌梗死)降低无关。文章5月5日在线发表于《美国心脏病学杂志》(Am J Cardiol)。 该分析共纳入4项随机对照研究(RCT)的8157例DES患者，其中4081例患者接受DAPT的时长为3~6个月(短期治疗组)，4076例为12~24个月(延长治

一项荟萃分析表明，与短期治疗相比，置入药物洗脱支架(DES)患者延长双联抗血小板治疗(DAPT)与大出血事件增加相关，但与复合终点发生率(死亡或心肌梗死)降低无关。文章5月5日在线发表于《美国心脏病学杂志》(Am J Cardiol)。

该分析共纳入4项随机对照研究(RCT)的8157例DES患者，其中4081例患者接受DAPT的时长为3~6个月(短期治疗组)，4076例为12~24个月(延长治疗组)。研究结果显示，短期治疗组和延长治疗组患者的复合终点(心源性死亡或心肌梗死)发生率无显著差异(3.3%对3.0%，P=0.41)，对短期治疗组患者停用DAPT的时间进行界标分析发现，停用DAPT的患者与继续应用者支架内血栓的发生率无显著差异(0.35%对0.20% ，P=0.22)，但DAPT延长治疗组患者大出血风险较短期治疗组患者显著增加(0.71%对0.29%，P=0.01)。








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    2014-10-25 仁者大医

    #Cardiol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1781672, encodeId=ca141e8167269, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Oct 25 03:08:00 CST 2014, time=2014-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429106, encodeId=d306142910630, content=<a href='/topic/show?id=168a3e464ad' target=_blank style='color:#2F92EE;'>#双抗治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37464, encryptionId=168a3e464ad, topicName=双抗治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6a4173831, createdName=zhangbaojun, createdTime=Sun May 18 02:08:00 CST 2014, time=2014-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487210, encodeId=8cb1148e21060, content=<a href='/topic/show?id=334b3e46139' target=_blank style='color:#2F92EE;'>#双抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37461, encryptionId=334b3e46139, topicName=双抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbaa8296156, createdName=yeye5224615, createdTime=Sun May 18 02:08:00 CST 2014, time=2014-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558489, encodeId=708a155848974, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Sun May 18 02:08:00 CST 2014, time=2014-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564498, encodeId=058c15644985e, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Sun May 18 02:08:00 CST 2014, time=2014-05-18, status=1, ipAttribution=)]
    2014-05-18 zhangbaojun

    #双抗治疗#

    0

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    2014-05-18 yeye5224615

    #双抗#

    0

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    2014-05-18 fusion

    #DES#

    0

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    2014-05-18 fusion

    #DES#

    0