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Oncotarget：lincRNA-p21有作为胃癌潜在生物标志物和重要治疗靶点的潜力

2017-08-02 Emma MedSci原创

胃癌长基因非编码RNA-p21过表达敲除
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lincRNA-p21，即长基因非编码RNA-p21，被称为p53直接转录靶，已发现其在几种人类实体瘤中下调。

lincRNA-p21，即长基因非编码RNA-p21，被称为p53直接转录靶，已发现其在几种人类实体瘤中下调。发表于oncotarget的一篇文章中，研究人员研究了lincRNA-p21在胃癌中的作用，结果提示，lincRNA-p21可以作为胃癌的潜在生物标志物和重要的治疗靶点。

研究人员通过qRT-PCR检测组织样本和细胞系中lincRNA-p21的表达水平，用针对lincRNA-p21或对照siRNA的siRNA转染MGC-803和MKN-45细胞，以确定减少的lincRNA-p21表达对肿瘤发生的影响。此外还在MGC-803细胞中过表达lincRNA-p21，通过CCK-8和Edu法测定细胞增殖情况，通过伤口愈合和transwell法测量细胞的迁移和侵袭能力。

结果显示，与正常组织相比，lincRNA-p21在胃癌组织中显著降低（p<0.001），而较低水平的lincRNA-p21与较高的侵袭深度等级（p = 0.024），较远的转移（p = 0.009）和晚期TNM期（p = 0.011）显著相关。进一步研究表明，敲除lincRNA-p21促进了胃癌细胞的恶性行为，并诱导上皮与间质转化（EMT），而过表达lincRNA-p21表现出相反的作用。此外，敲除lincRNA-p21可以通过升高mRNA水平和增加其细胞核易位而不是典型的Hippo途径来提高Yes相关蛋白（YAP，Hippo信号的核心效应物）的表达，过表达实验也证实了lincRNA-p21在YAP表达中的调节作用。

原始出处：
doi: 10.18632/oncotarget.19130.

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    2017-09-13 tulenzi

    #p21#

    0

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    2017-10-20 zutt

    #lincRNA#

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    2018-05-28 hukaixun

    #标志物#

    0

  4. 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    2018-03-21 drj2003

    #治疗靶点#

    0

  5. 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    2018-03-06 仁医06

    #target#

    0

  6. 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style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Aug 04 07:01:00 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566646, encodeId=40c3156664638, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Aug 04 07:01:00 CST 2017, time=2017-08-04, status=1, ipAttribution=), 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    2017-08-29 海之蓝

    学习

    0

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GetPortalCommentsPageByObjectIdResponse(id=229284, encodeId=7f902292849d, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Aug 02 20:01:59 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2018-06-14 yanjie6253_56072842

    #CRN#

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=229284, encodeId=7f902292849d, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Aug 02 20:01:59 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-04 zhu_jun9842

    #生物标志#

    0

  9. 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    2017-08-04 zhu_jun9842

    #生物标志#

    0

  10. 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    2017-08-02 184****9840

    学习了受益匪浅

    0

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研究证实表皮生长因子抑制剂可预防幽门螺杆菌感染导致的胃癌变

Clin Cancer Res：胃癌分子分型、预后及疗效的关系

发表在美国癌症研究学会（American Association for Cancer Research）官方期刊Clinical Cancer Research上的一篇文章称，胃癌的四种分子分型有助于预测生存预后及患者的化疗效果，因此可能有望进一步精确指导治疗方案的制定。 德克萨斯大学MD安德森肿瘤中心癌症医学部系统生物学副教授Lee博士介绍道，胃癌大部分都会行手术治疗，其次行化疗。不过，这些

HMGA2-FOXL2轴调节化疗抵抗胃癌的远处转移及上皮间质化

化疗是晚期肿瘤的主要治疗策略。化疗可以减轻肿瘤负担并延长患者生存期，其治疗效果已得到证实。但是大部分患者最终会出现化疗抵抗。化疗抵抗是肿瘤治疗过程中失败的主要原因，且与远处转移和上皮间质化（EMT）有关。CLIN CANCER RES近期发表了一篇文章，研究化疗抵抗胃癌远处转移及上皮间质化机制。

Oncotarget：HADH表达下降通过激活Akt信号通路促进胃癌发展

胃癌的扩散和转移途径有直接浸润、血行转移、腹膜种植转移以及淋巴转移，其中淋巴转移是胃癌的主要转移途径，进展期胃癌的淋巴转移率高达70%左右，早期胃癌也可有淋巴转移。

Br J Cancer：胃癌血清微小RNA生物标志物评估：miR-21和miR-331的重要性

胃癌（GC）是全球第三大癌症和全球重大的公共医疗保健问题，其中包括西方人群。 一些亚洲国家只有少数有限的早期检测诊断方法而且没有有效的筛查方案。 因此，大多数病例被诊断为晚期，预后不佳。 因此，迫切需要寻找新的、非侵入性的生物标志物，以便早期检测GC。 高稳定性和疾病特异性的错配表明体液中存在的微小RNA分子（miRNA），非常适用于包括胃癌（GC）在内的诊断应用。 然而，GC中循环miRN