Obstet Gynecol:胎儿生长受限是早产儿死亡高危因素!

2015-12-18 MedSci译 MedSci原创

研究者对孕24-34周出生的早产儿进行了一项研究,探究早产原因对早产儿院内死亡的影响。EPIPAGE-2是一项关于极早产儿的全国性基于人群的前瞻性研究,根据早产原因的不同研究组将研究对象分为六大组,校正孕产妇、产科等相关因素后,探究早产原因与早产儿死亡之间的联系。该研究共纳入了 3,138名24-34周出生的单胎早产儿,院内死亡率为 5.0% (95% CI 4.5-5.7)。未足月出现宫缩阵痛是

研究者对孕24-34周出生的早产儿进行了一项研究,探究早产原因对早产儿院内死亡的影响。EPIPAGE-2是一项关于极早产儿的全国性基于人群的前瞻性研究,根据早产原因的不同研究组将研究对象分为六大组,校正孕产妇、产科等相关因素后,探究早产原因与早产儿死亡之间的联系。

该研究共纳入了 3,138名24-34周出生的单胎早产儿,院内死亡率为 5.0% (95% CI 4.5-5.7)。未足月出现宫缩阵痛是导致早产最常见的原因(n=1,293 [43.5%]) ,未足月胎膜早破是诱发早产第二大因素(n=765 [23.9%]),接下来分别是不含胎儿生长受限的高血压疾病(n=397 [12.7%]),可疑胎儿生长受限的高血压疾病(n=408 [10.9%]),不含妊娠并发症的胎盘早剥(n=92 [3.0%]),可疑胎儿生长受限不伴高血压疾病(n=183 [5.9%])。

研究者发现胎儿生长受限伴或不伴高血压疾病导致的早产其院内死亡率高于未足月宫缩阵痛导致的早产(伴高血压疾病:aOR 3.0 [1.9-4.7];不伴高血压疾病:aOR 2.3 [1.1-4.6])。其余早产原因导致院内死亡的因素如未足月胎膜早破(aOR 1.3 [0.9-1.9])、不含胎儿生长受限的高血压疾病 (aOR 0.7 [0.4-1.4])、胎盘早剥(aOR 1.6 [0.7-3.7])等均是通过胎儿生长受限导致早产儿院内死亡。

研究结果表明,孕34周出生的早产儿,若可疑胎儿生长受限,早产后死亡风险更高!

原始出处:


Delorme P, Goffinet F, Ancel PY,et al.Cause of Preterm Birth as a Prognostic Factor for Mortality.Obstet Gynecol. 2015 Dec 7.

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    2016-08-11 yhy100200
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    2016-01-28 1de3b290m83(暂无匿称)

    基础病

    0

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    2015-12-26 hixiaoluo

    值得看,好好收藏

    0

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