为什么头发越来越少？因为头皮越来越多

2016-04-19 魏昕宇编译科学公园

随着年龄的增长，人的头发逐渐变得稀疏，这是众所周知的事实，但是这种现象究竟为什么会发生？一项新的研究揭开了谜团：衰老导致毛囊干细胞逐渐变为表皮角质细胞，从而使得毛囊失去了生长头发的能力。（图片来源：http://www.midwest-antiaging.com/facial-treatments/prp-hair-restoration/）来自日本等国的研究人员通过对小鼠进行实验表明，随着年龄的

随着年龄的增长，人的头发逐渐变得稀疏，这是众所周知的事实，但是这种现象究竟为什么会发生？一项新的研究揭开了谜团：衰老导致毛囊干细胞逐渐变为表皮角质细胞，从而使得毛囊失去了生长头发的能力。

（图片来源：http://www.midwest-antiaging.com/facial-treatments/prp-hair-restoration/）

来自日本等国的研究人员通过对小鼠进行实验表明，随着年龄的增加，毛囊干细胞DNA的不断受损会导致细胞中一种名为Collagen 17A1的胶原蛋白发生酶解而被破坏，而这种蛋白的被破坏又导致毛囊干细胞转化为表皮角质细胞并脱落。这会导致毛囊逐渐缩小，最终彻底变成表皮组织，失去了再生毛发的能力。而如果让Collagen 17A1过度表达，毛囊干细胞向表皮角质细胞的转化就会受到抑制。随后研究人员又对不同年龄段的妇女的毛囊情况进行了比较，结果发现随着年龄的增长，毛囊确实变得越来越小，而Collagen 17A1的含量也在降低，表明人的衰老导致的头发稀疏同样是由于这种机理导致。这项研究发表在最新一期的《科学》杂志上。

这一期的《科学》杂志还报道了另一项有关毛发生长的研究。毛囊干细胞会交替进入生长和休眠阶段，在休眠阶段不会有新的毛发生长出来。来自美国的研究人员发现，Foxc1这种转录因子能够调节毛囊干细胞的这种循环，而扰乱它的表达则会干扰毛囊干细胞在两种状态之间的转变。这两项研究有助于我们更好地了解头发的生长。

原始出处：

Hiroyuki Matsumura1,*, Yasuaki Mohri1,*, Nguyen Thanh Binh1,2,*, Hironobu Morinaga1, Makoto Fukuda1, Mayumi Ito3, Sotaro Kurata4, Jan Hoeijmakers5, Emi K. Nishimura1,†.Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.Science 05 Feb 2016:Vol. 351, Issue 6273, DOI: 10.1126/science.aad4395

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2016-04-23 吴玲

理论知识又多学了一个

117 0
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2016-04-21 qindq

#头发#

39 0
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2016-04-20 文医生

感觉人能健康活着真是不容易啊

85 0
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2016-04-20 醉清风

脱发控制不住

143 0
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2016-04-19 qq1e1c69fe

学习啦！

131 0
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2016-04-19 qian0416

长知识了，学习～

186 0
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2016-04-19 李继凯

长知识啊

109 0
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2016-04-19 李继凯

原来如此

56 0
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2016-04-19 hewenda

涨知识了，不错

94 0

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