Graefes Arch Clin Exp Ophthalmol.:神经节细胞层切片和双闪多焦视网膜电图改善早期青光眼的结构功能分析。

2017-08-07 cuiguizhong MedSci原创

瑞士巴塞尔大学眼科系的Brandao LM近日在Graefes Arch Clin Exp Ophthalmol杂志上发表了一项有趣的工作,标题为"Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early g

瑞士巴塞尔大学眼科系的Brandao LM近日在Graefes Arch Clin Exp Ophthalmol杂志上发表了一项有趣的工作,标题为"Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma",他们通过双全局闪光多焦视网膜电图(2F-mfERG)和黄斑神经节细胞层切片相结合的办法,提高对原发性开角型青光眼(POAG)的结构和功能之间的分析。


他们对25例青光眼患者(6例预处理(PPG),19例POAG)和16例对照组分别进行了2F-mfERG,光学相干断层扫描(OCT)和标准自动视野测量(SAP)。对于2F-mfERG,计算在15-45ms(DC)下的焦点闪光响应的均方根和45-75ms(IC1)和75-105ms(IC2)的全局闪光响应。对于OCT,分析黄斑总厚度(mT)和神经节细胞内丛状层(GCIPL)厚度。将来自2F-mfERG的中心10°和15°的值与OCT和视野的相应区域进行比较。


他们发现,在中心10°和15°时,PPG和POAG比对照组明显降低mfERG反应。在青光眼患者中,30.7%(三个PPG,五个POAG)显示中心mfERG和GCIPL减少,而在中心15度没有明显的SAP缺陷。 4例患者出现中枢性SAP缺陷,伴有GCIPL降低,mfERG无明显功能障碍。 随着mT厚度增加,MfERG DC和IC2也增大(p≤0.02),但GCIPL仅与IC2呈正相关性(p = 0.027)。 SAP灵敏度也随着mT增加而增加,但GCIPL没有增加(p <0.03和p = 0.35)。 DC,IC2和GCIPL可以最好地区分青光眼与对照(AUC值:0.897,0.903和0.905)。


因此,他们认为,当测量数据包括SAP的补充信息,如GCIPL厚度和2F-mfERG时,对青光眼的结构功能分析有显着的提高作用。


原文出处:


Brandao, L.M., et al., Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma. Graefes Arch Clin Exp Ophthalmol, 2017.


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    2017-08-13 王晓霞

    学习

    0

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    2017-08-09 zutt
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    2017-08-09 chunjianf

    学习了,谢谢分享

    0

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    2017-08-08 刘煜

    学习了谢谢分享

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    2017-08-08 龙胆草

    学习谢谢分享

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