Hepatology:非酒精性脂肪性肝病患者适度饮酒是好是坏?

2017-06-30 吴刚 环球医学

非酒精性脂肪性肝病(NAFLD)患者适度饮酒很常见,然而其对心血管和肝健康的影响未知。适度饮酒可改善普通人群的胰岛素敏感性,降低心血管死亡率,但是NAFLD患者中,是否也存在相似的获益仍然未进行过研究。2017年6月,发表在《Hepatology.》的一项研究调查了NAFLD患者适度饮酒是否获益。酒精性肝病(ALD)和NAFLD的发病机制具有显着的重叠,然而ALD的研究关注于病理性酒精摄入,很少有




非酒精性脂肪性肝病(NAFLD)患者适度饮酒很常见,然而其对心血管和肝健康的影响未知。适度饮酒可改善普通人群的胰岛素敏感性,降低心血管死亡率,但是NAFLD患者中,是否也存在相似的获益仍然未进行过研究。2017年6月,发表在《Hepatology.》的一项研究调查了NAFLD患者适度饮酒是否获益。

酒精性肝病(ALD)和NAFLD的发病机制具有显着的重叠,然而ALD的研究关注于病理性酒精摄入,很少有NAFLD适度饮酒的机理研究。研究人员进行了一项NAFLD患者中,适度饮酒对心血管和肝病影响的述评。

总共7项观察性研究符合入组标准(1项为心血管终点,6项为肝脏终点)。不充分的研究评估了适度饮酒与心血管结局之间的相关性。适度饮酒与非酒精性脂肪性肝炎(NASH)和肝纤维化的降低之间具有正相关性,然而,重度饮酒可加速肝纤维化的进展,适度饮酒会增加晚期肝纤维化患者肝细胞肝癌的风险。研究具有显着的方法学局限性,包括混杂因素的不完全调整和未能测量终生使用或饮酒模式。因此,不能得出NAFLD患者适度饮酒获益的强烈建议。仍然需要额外的高质量纵向研究评估NAFLD患者适度饮酒或较低程度饮酒的心血管和肝脏结局。

原始出处:

Ajmera VH, Terrault NA, Harrison SA. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review. Hepatology. 2017 Jun;65(6):2090-2099. doi: 10.1002/hep.29055. Epub 2017 Apr 28.

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    2017-07-02 qjddjq
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    2017-07-02 gwc384
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    2017-06-30 楠博One

    都认为脂肪肝不适应饮酒

    0

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