Diabetologia:关于身体活动和2型糖尿病的关系,你知道多少?

2016-10-22 MedSci MedSci原创

身体活动(PA)和2型糖尿病之间的反向相关性是众所周知的。然而,剂量-反应关系的形状仍然是不确定的。本综述综合了纵向研究在一般人群中的结果,并使用非线性模型来评估PA和2型糖尿病事件之间的关联。该研究经过系统的文献检索,确定了28项关于休闲时间PA(LTPA)或总PA和2型糖尿病风险关系的前瞻性研究。PA暴露被转化为代谢当量(MET)h/周的和边际MET(MMET)h /周。研究人员使用限制三次样

身体活动(PA)和2型糖尿病之间的反向相关性是众所周知的。然而,剂量-反应关系的形状仍然是不确定的。本综述综合了纵向研究在一般人群中的结果,并使用非线性模型来评估PA和2型糖尿病事件之间的关联。

该研究经过系统的文献检索,确定了28项关于休闲时间PA(LTPA)或总PA和2型糖尿病风险关系的前瞻性研究。PA暴露被转化为代谢当量(MET)h/周的和边际MET(MMET)h /周。研究人员使用限制三次样条来模拟暴露-疾病关系。

该研究结果表明了一种总体非线性关系;通过使用三次样条模型,研究人员发现,与那些没有身体活动的人群相比,达到11.25MET h/周(相当于150分钟/周的中度活动)的人群2型糖尿病风险降低26%(95%CI 20%,31%)。实现两倍上述PA量的人群,患2型糖尿病的风险可降低36%(95%CI 27%,46%),如果PA能够达到更高剂量,则风险会进一步降低(60 MET h/周,风险降低53%)。MMET h/周剂量 - 反应曲线的结果对于中等强度的PA是相似的,但是对于较高强度的PA,益处更大,而对于较低强度的PA,则益处更小。

在普通人群中,较高水平的LTPA与2型糖尿病发病率较低显著相关。LTPA和2型糖尿病之间呈曲线的关系;在较低的活动水平时可实现最大的相对益处,但是当暴露量比公共卫生建议规定的量高得多时可以实现额外的益处。

原始出处:

Andrea D. Smith,Alessio Crippa,James Woodcock,Physical activity and incident type 2 diabetes mellitus,Diabetologia,2016.10.22

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    2016-11-08 sophia0225

    学习了,太棒了

    0

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    2016-10-25 1e10c84am36(暂无匿称)

    糖尿病患者越来越多,普及相关知识有必要

    0

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    2016-10-22 图院长

    长知识啦~

    0

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