ARCH PATHOL LAB MED:胆囊上皮内的胞质纤维聚集体与儿童胆囊切除标本中的膀胱异孢菌相似?

2019-10-24 MedSci MedSci原创

膀胱异孢菌是一种胞内寄生虫,与免疫缺陷宿主的胃肠道疾病有关。

膀胱异孢菌是一种胞内寄生虫,与免疫缺陷宿主的肠道疾病有关。虽然传统上认为感染肠道疾病有关,但研究已根据苏木精-伊红形态学在免疫功能正常的患者胆囊中发现了膀胱异孢菌。最近,由于核酸监测结果阴性,这一组织学发现膀胱异孢菌一直受到质疑。为了确定这一组织学特征在儿科患者中的患病率,我们回顾了24个月期间从儿科医院收集的所有胆囊切除标本。

180例胆囊切除术标本中,我们确定了11(6.1%)具有先前描述的代表膀胱异孢菌的经典组织学特征。为了进一步研究这些结构,我们从石蜡包埋的组织块中提取组织并进行了电子显微镜检查。

超微结构检查发现卵圆形核周细胞质结构由致密的纤维聚集物组成,而不是生物体。阳性病例年龄与对照组相似(阳性病例:平均年龄13.4[范围,2-23];阴性病例:平均年龄14.7[范围:12- 31];P = .35)。这一发现与胆石症(54.5%65.1%P = .52)胆固醇(0%22.5%P = .12)、急性胆囊炎(9.1%10.1%P > .99)或慢性胆囊炎(45.5%66.3%P = .20)没有显著的相关性。

据我们所知,这是首次通过超微结构检查确定这些结构为细胞质纤维聚集体,而不是寄生包涵体,这也是首次在儿童胆囊切除术中研究这一组织学发现。

原始出处:

Gary S. Rose, MD; Christina A. Arnold, MD;Cytoplasmic Fibrillar Aggregates in Gallbladder Epithelium Are a Frequent Mimic of Cystoisospora in Pediatric Cholecystectomy Specimens

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    2020-05-01 yb6560
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    2019-10-24 147612bem32暂无昵称

    写的真好

    0