华西医院成功实施离体肝切除联合自体肝移植治疗晚期肝包虫病患者

2014-03-25 驻地记者华西医院朱方 医学论坛网

2014年2月24日,华西医院肝脏外科及肝移植中心副主任王文涛教授在介入治疗中心、血管外科、麻醉科、重症医学科、手术室的大力配合下,成功实施了我院首例离体肝切除、联合自体肝移植治疗晚期肝包虫病患者。 西藏达江县44岁的藏族妇女,患“肝包虫病”多年,病情逐渐明显加重恶化,合并梗阻性黄疸及凝血功能障碍,病变已完全侵蚀肝后腔静脉、肝门胆管、血管结构,

2014年2月24日,华西医院肝脏外科及肝移植中心副主任王文涛教授在介入治疗中心、血管外科、麻醉科、重症医学科、手术室的大力配合下,成功实施了我院首例离体肝切除联合自体肝移植治疗晚期肝包虫病患者

西藏达江县44岁的藏族妇女,患“肝包虫病”多年,病情逐渐明显加重恶化,合并梗阻性黄疸及凝血功能障碍,病变已完全侵蚀肝后腔静脉、肝门胆管、血管结构,肝脏受侵犯严重,8个肝段中仅有2个肝段存在略正常结构,已失去手术切除指征。患者曾多次到国内大型医院就诊,均认为无法手术治疗。2013年12月因合并严重黄疸和凝血功能障碍来华西医院就诊。先由该院介入治疗中心先期进行了经皮肝穿刺胆道引流术(PTCD)和支持治疗,经近2月的前期治疗,患者一般情况得到改善后,王文涛教授联合相关科室,反复多科讨论后,决定行离体肝切除、联合自体肝移植术。

手术于2月24日上午8时开始,打开腹腔后,看到腹腔内广泛的粘连和已经没有正常外型的肝脏,经过4个小时的努力切除了病肝,在体外将切出肝脏仔细分离、切除病变部分,将切除病变后剩余的2个肝段的入肝和出肝的重要管道结构进行修补、成型。与此同时,用人造血管临时性重建下腔静脉,行门腔静脉的分流以维持全身循环的稳定,并用患者自身其他部位的血管成型来重建下腔静脉。最后将完全切除了病变的少部分肝脏植回病人体内。经过16位医生18个小时的努力,于次日凌晨2时手术顺利结束。术后患者恢复良好,各项指标已基本恢复正常,于3月15日痊愈出院。

我国是肝病大国,肝移植术是目前对于肝脏终末期疾病唯一有效的治疗方案,全球器官移植都面临着供器官短缺、术后需要长期使用免疫排斥药物等问题,治疗费用昂贵,而且长期服用免疫抑制剂后会出现药物副作用和原有疾病的复发等情况。离体肝切除联合自体肝移植具有无需其他供体、术后不需要服用抗免疫排斥药物、费用低等优点。但手术难度大、风险高。这一手术方式是目前国际上在活体肝脏移植技术和理念的基础上的进一步创新,是肝脏外科领域最高难度的新探索。这一技术也可以延伸应用于各种无法常规切除的肝脏疾病。

经文献检索,晚期肝包虫病的离体切除联合自体肝移植,国内外仅有2家医疗机构报道了8例此类手术,国内综合排名前20家的大型医院均未开展过此类手术。

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    2014-12-27 changfy
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    2014-03-27 fengyqf
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