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Front Microbiol：厚叶岩白菜可抑制变形链球菌生物膜的形成

2018-04-14 MedSci MedSci原创

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已知变形链球菌是与龋齿相关的主要致龋病原体。细菌可以产生葡糖基转移酶（Gtfs）来合成胞外多糖（EPSs），EPSs为用于粘附和形成生物膜的毒力因子。因此，理想的龋齿抑制剂可抑制浮游细菌生长并防止生物膜形成。据研究报道，广泛用作民间药物和茶饮料的厚叶岩白菜（L.）具有多种生物活性。本研究旨在探讨厚叶岩白菜（L.）提取物对变形链球菌生物膜的影响。通过XTT测定、活/死染色和LDH活性测定显示，厚叶岩

已知变形链球菌是与龋齿相关的主要致龋病原体。细菌可以产生葡糖基转移酶（Gtfs）来合成胞外多糖（EPSs），EPSs为用于粘附和形成生物膜的毒力因子。因此，理想的龋齿抑制剂可抑制浮游细菌生长并防止生物膜形成。据研究报道，广泛用作民间药物和茶饮料的厚叶岩白菜（L.）具有多种生物活性。

本研究旨在探讨厚叶岩白菜（L.）提取物对变形链球菌生物膜的影响。通过XTT测定、活/死染色和LDH活性测定显示，厚叶岩白菜（L.）叶提取物可降低生物膜内的细菌的存活力，并可通过抑制Gtfs合成EPs降低变形链球菌的粘附力。另外，EPS的减少量和Gtfs的抑制与测试样品的浓度呈正相关。最后，MTT测定显示提取物对正常口腔细胞没有细胞毒性。

总之，厚叶岩白菜提取物和亚提取物具有抗菌作用，并且可以通过抑制Gtfs的活性从而减少EPSs合成来防止细菌粘附和生物膜形成。因此，厚叶岩白菜叶子或可用于预防和治疗龋齿。

原始出处：

Liu Y, Xu Y, et al., Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans. Front Microbiol. 2017 Sep 13;8:1738. doi: 10.3389/fmicb.2017.01738. eCollection 2017.

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    2019-02-13 爆笑小医

    #CRO#

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    2019-03-14 xjy02

    #Micro#

    0

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    2019-02-23 12498ebem31暂无昵称

    #Biol#

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    2019-02-17 sunylz

    #Bio#

    0

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    2018-04-16 liuquanmn

    #链球菌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1857622, encodeId=a431185e62299, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Feb 13 10:18:00 CST 2019, time=2019-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084377, encodeId=318720843e7b6, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Mar 14 10:18:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767422, encodeId=a8dc1e6742214, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Feb 23 17:18:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918032, encodeId=be1c1918032fe, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Feb 17 17:18:00 CST 2019, time=2019-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624056, encodeId=6e05162405681, content=<a href='/topic/show?id=69699666026' target=_blank style='color:#2F92EE;'>#链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96660, encryptionId=69699666026, topicName=链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787f20641298, createdName=liuquanmn, createdTime=Mon Apr 16 14:18:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305996, encodeId=1e6b30599616, content=一起学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sun Apr 15 10:56:17 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-15 wzb521zf

    一起学习学习学习

    0