Eur Heart J:血浆甘油三酯升高可增加主动脉瓣狭窄发生风险

2020-06-30 MedSci原创 MedSci原创

本研究的目的旨在验证血浆甘油三酯和残余胆固醇水平的升高与主动脉瓣狭窄风险的增加有关。

本研究的目的旨在验证血浆甘油三酯和残余胆固醇水平的升高与主动脉瓣狭窄风险的增加有关。

本研究纳入分析了108559名研究对象,对其血浆甘油三酯、残余胆固醇和16种基因变异导致这种水平的增加或减少进行了检测。共有1593名患者发生主动脉瓣狭窄,与甘油三酯<1mmol/L(<89mg/dL)的个体相比,甘油三酯浓度为1.0-1.9?mmol/L(89-176mg/dL)的个体主动脉瓣狭窄的多因素校正危险比为1.02[95%可信区间(CI)0.87-1.19],2.0-2.9mmol/L(177-265mg/dL)的主动脉瓣狭窄的为1.22(1.02-1.46),3.0-3.9毫摩尔/升(266-353毫克/分升)的为1.40(1.11-1.77),4.0-4.9毫摩尔/升(354-442毫克/分升)的为1.29(0.88-1.90),甘油三酯≥5毫摩尔/升(≥443毫克/分升)的为1.52(1.02-2.27)。在残余胆固醇和遗传水平也有类似的相应趋势。

研究结果显示,血浆甘油三酯和残余胆固醇水平的升高与主动脉瓣狭窄风险的增加有关。

原始出处:

Morten K et al.Triglycerides and remnant cholesterol associated with risk of aortic valve stenosis: Mendelian randomization in the Copenhagen General Population Study.Eur Heart J.2020 June.

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    2020-07-02 zhaojie88
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    2020-07-02 slcumt

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