BMJ:试验注册与阳性研究结果之间有啥关系吗?

2017-03-16 xing.T MedSci原创

在已发表的RCTs中,很少有证据表明在注册和非注册的临床试验之间存在阳性研究结果的差异,即使根据注册时间进行了分层。在企业和非企业资助的亚群中相对风险估计并不准确。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在评估注册的随机对照试验(RCT)相比于未进行注册的RCT是否不太可能报告阳性的研究结果,并且这种相关性随着资金来源而变化。该研究为横断面研究,研究人员纳入了所有发表于2012年12月并于2013年11月在pubmed被索引的主要RCTs。试验注册的确定是根据已发表的RCTs报告的注册号或在试验登记处确认的试验。试验被分为前瞻性和回顾性注册研究。该研究的主要结局指标为试验注册和阳性研究结果之间的相关性。研究人员共确定了1122个符合条件的RCTs,其中登记注册的有593个(52.9%),未登记注册的有529个(47.1%)。总体而言,注册与阳性的研究结果轻微相关(调整后的风险比为0.87,95%可信区间为0.78-0.98),即使按照前瞻性和回顾性注册试验进行分层(分别为0.87,0.74-1.03和0.88,0.78-1.00)。整体注册和资金来源之间的相互关系只有轻微的统计显著性,并且相对风险估计不精确(非企业资助为0.75,0.63-0.89,企业资助为1.03,0.79-1.36,P相互作用=0.046)。此外,在敏感性分析中

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    2018-01-26 gaoxiaoe
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    2017-05-07 laoli

    学习了,谢谢分享!

    0

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    2017-03-21 虈亣靌

    学习一下很不错

    0

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    2017-03-18 zhyy93
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    2017-03-17 虈亣靌

    好提议,学习了

    0

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    2017-03-16 1de11f7fm56(暂无匿称)

    学习了,非常好的研究,谢谢分享

    0

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    2017-03-16 天涯183

    非常好的研究

    0

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