J Periodontal Res: 吸烟对种植体周围微生物群的调节作用

2018-12-30 MedSci MedSci原创

吸烟是种植体周围疾病的公认风险因素,并导致粘膜炎和种植体周围炎的微生物变化。然而,吸烟对健康的种植体周围组织的影响未知。该研究的目的是评估具有健康种植体周围条件的吸烟者在种植体周围环境中的微生物组。

吸烟是种植体周围疾病的公认风险因素,并导致粘膜炎和种植体周围炎的微生物变化。然而,吸烟对健康的种植体周围组织的影响未知。该研究的目的是评估具有健康种植体周围条件的吸烟者在种植体周围环境中的微生物组。

方法:在12名非吸烟者(NSMK)和12名吸烟者(SMK)非牙周炎患者(无出血和探诊深度<4 mm)的单个临床健康,螺钉固位,有邻牙的种植体周围收集种植体周围生物膜。提取细菌DNA,并使用焦磷酸测序对16S核糖体RNA基因文库进行测序,靶向V3-V4区域。使用Quantitative Insights into Microbial Ecology,Greengenes和Human Oral Microbiome Database数据库处理数据集。

结果:与NSMK微生物组相比, SMK种植体周围微生物组有明显差异,即使具有健康的种植体周围也具有大量菌种。 SMK核心 - 微生物组显示出丰富的梭杆菌属,Tannerella和Mogibacterium,而NSMK核心显示出大量的放线菌,Capnocytophaga和Streptococcus属,通常与牙周健康有关。smk的微生物群间亲缘关系比nsmk中的微生物群间的亲缘关系更强,说明不同的微生物群内聚力存在差异。

吸烟对种植体外微生物组产生负面影响,导致疾病相关的状态,即使在临床健康的个体中也是如此。

原始出处:

Suzana P. Pimentel,et al. Smoking habit modulates peri‐implant microbiome: A case‐control study.Journal of Periodontal Research.2018 Decemember. Doi:10.1111/jre.12597

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    2019-10-19 huangdf
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    2019-04-30 feather89
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