JAHA:肺动脉高压患者妊娠结局分析!

2017-10-25 xing.T MedSci原创

这个研究数据表明,PH与住院分娩期间发生MACE的几率增加有关,其中伴有相关心肌病的妇女风险尤其高。

肺动脉高压(PH)孕妇具有心脏不良结局的风险,特别是在分娩时。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是明确PH对妊娠结局和主要不良心脏事件(MACE)风险的影响。

在2003年至2012年期间,全国住院病人样本筛查了住院分娩的女性。该研究的主要结局为MACE,即死亡、心脏骤停、心源性休克、心肌梗死、呼吸衰竭、心律失常、卒中和栓塞事件。该研究共对1519例PH患者和6757582例无心脏病或PH的患者资料进行分析。

59.6%的PH患者为孤立性PH患者,10.7%患有PH和先天性心脏病;,18.1%患有PH和瓣膜性心脏病,3%患有PH和瓣膜性心脏病和先天性心脏病,6.6%患有PH和心肌病,1.9%患有PH和心肌病以及瓣膜性心脏病。与没有心脏病或PH的妇女相比,患有PH的妇女发生MACE几率的明显升高(24.8% vs. 0.4%,P<0.0001)。在患有PH的女性亚组中,在患有PH和心肌病以及瓣膜性心脏病的患者以及患有PH和心肌病的患者中,发生MACD的几率最高,主要是由于心力衰竭和心律失常。患有PH的妇女更有可能发生子痫综合征、早产和子宫内胎儿死亡(P<0.0001)。多变量分析中,PH亚型与MACE显着相关(P <0.001)。

这个研究数据表明,PH与住院分娩期间发生MACE的几率增加有关,其中伴有相关心肌病的妇女风险尤其高。

原始出处:


Erin Thomas, et al. Pulmonary Hypertension and Pregnancy Outcomes: Insights From the National Inpatient Sample.JAHA.2017. https://doi.org/10.1161/JAHA.117.006144

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    2017-10-27 zhaohui6731
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    2017-10-25 惠映实验室

    学习了.谢谢.

    0

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    2017-10-25 惠映实验室

    学习了谢谢

    0

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