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BMJ：类固醇5α还原酶抑制剂与II型糖尿病风险

2019-04-21 MedSci MedSci原创

类固醇5α还原酶抑制剂糖尿病良性前列腺增生
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研究认为使用5α还原酶抑制剂治疗良性前列腺增生患者新发II型糖尿病风险增加，其中坦索洛辛风险较低，而服用度他雄胺和非那司提治疗的男性风险均较高

近日研究人员探讨了类固醇5α还原酶抑制剂(度他雄胺或非那司提)长期治疗良性前列腺增生对II型糖尿病风险的影响

本次研究为基于人口的队列研究，考察了英国临床实践研究数据链 (CPRD；2003-14)和台湾国家医疗保险研究数据库(NHIRD；2002-12)。CPRD数据中，度他雄胺、非那司提或坦索洛新的使用者分别为2090、3445和4018例。在NHIRD数据库中分别为1251、2445和2502例。研究的主要终点为II型糖尿病事件。

CPRD数据库中，在5.2年的平均随访时间中，记录了2081例新发的II型糖尿病事件(度他雄胺368例、非那司提1207例和坦索洛新506例)。每10000人随访年的事件发生率为度他雄胺76.2、非那司提76.6、坦索洛新为60.3。与坦索洛新相比，度他雄胺(HR=1.32)和非那司提(HR=1.26)使用者的II型糖尿病风险适度增加。NHIRD与CPRD的结果一致，与坦索洛新相比，度他雄胺和非那司提风险分别为1.34和1.49。

研究认为使用5α还原酶抑制剂治疗良性前列腺增生患者新发II型糖尿病风险增加，其中坦索洛辛风险较低，而服用度他雄胺和非那司提治疗的男性风险均较高。

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    2019-09-17 jklm09

    #抑制剂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1851977, encodeId=17a018519e747, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Sep 17 20:45:00 CST 2019, time=2019-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848737, encodeId=83241848e3724, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu May 23 08:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313428, encodeId=9691131342836, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Apr 23 06:45:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429713, encodeId=d9491429e1332, content=<a href='/topic/show?id=9a8d9592b0' target=_blank style='color:#2F92EE;'>#II型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9592, encryptionId=9a8d9592b0, topicName=II型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d7914226234, createdName=lsj629, createdTime=Tue Apr 23 06:45:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042394, encodeId=3c95104239441, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Apr 21 18:45:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
    2019-05-23 gaoxiaoe

    #BMJ#

    0

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    2019-04-23 30397604

    #类固醇#

    0

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    2019-04-23 lsj629

    #II型糖尿病#

    0

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    2019-04-21 misszhang

    谢谢MedSci提供最新的资讯

    0