Biomaterials:三功能聚醚醚酮可有效行使抗菌和成骨的功能

2019-05-25 不详 网络

聚醚醚酮(PEEK)因其优异的机械和化学性质(例如,与人骨相似的弹性模量)被认为是潜在的整形外科/牙科材料。然而,生物惰性PEEK的较差的抑菌和抗炎以及骨整合性阻碍了其临床应用。我们以前开发了一种简便易用的表面修饰方法,使用地塞米松和米诺环素负载的脂质体(Dex/Mino脂质体)通过贻贝激发的聚多巴胺涂层结合,有效调节细胞炎症反应并阻止体外细菌定植。本研究中,我们报告了这种多功能表面修饰方法的应用

聚醚醚酮(PEEK)因其优异的机械和化学性质(例如,与人骨相似的弹性模量)被认为是潜在的整形外科/牙科材料。然而,生物惰性PEEK的较差的抑菌和抗炎以及骨整合性阻碍了其临床应用。我们以前开发了一种简便易用的表面修饰方法,使用地塞米松和米诺环素负载的脂质体(Dex/Mino脂质体)通过贻贝激发的聚多巴胺涂层结合,有效调节细胞炎症反应并阻止体外细菌定植。

本研究中,我们报告了这种多功能表面修饰方法的应用,以改善生物惰性PEEK,旨在进一步研究Dex/Mino脂质体修饰的PEEK的体外成骨和体内特性,以防止细菌污染,减弱炎症反应,并增强骨化用于生理性骨整合。

结果显示,Dex/Mino脂质体修饰的PEEK表面具有良好的稳定性和细胞相容性。与裸PEEK相比,由于脂质体Dex释放,在功能化表面上发现了在骨诱导和骨传导条件下人间充质干细胞的成骨分化改善。体内抑菌试验证实,从功能化表面释放的Mino提供了有效的抗菌作用。此外,皮下异物反应和比格犬股骨植入模型证实了功能化PEEK的增强的抗炎和骨整合特性。我

综上所述,该研究结果表明,开发的具有增强的抗菌,抗炎和骨整合能力的Dex/Mino脂质体修饰的PEEK作为临床应用的整形外科/牙科植入材料具有巨大的潜力。

原始出处:

Xu X1, Li Y2, et al., Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application. Biomaterials. 2019 May 11;212:98-114. doi: 10.1016/j.biomaterials.2019.05.014.

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    2019-11-15 sunylz
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    2019-05-27 zhouqu_8