Clin Oral Investig:牙周治疗对伴有类风湿性关节炎的牙周炎患者的效果

2018-04-06 MedSci MedSci原创

本研究旨在对比非手术牙周治疗对伴有类风湿性关节炎(RA)的中重度慢性牙周炎(CP)的患者(RA-CP)和与未伴有RA的CP患者的临床和炎症指标的影响。研究共纳入了18例RA-CP患者和18例系统健康的CP患者,24小时内接受了洁治和根面平整(SRP)治疗。在基线时和SRP后3个月和6个月时,评估临床牙周参数,炎症标志物和龈下生物膜中的微生物。另外,监测RA-CP组中RA的疾病活性标记(DAS28,

本研究旨在对比非手术牙周治疗对伴有类风湿性关节炎(RA)的中重度慢性牙周炎(CP)的患者(RA-CP)和与未伴有RA的CP患者的临床和炎症指标的影响。

研究共纳入了18例RA-CP患者和18例系统健康的CP患者,24小时内接受了洁治和根面平整(SRP)治疗。在基线时和SRP后3个月和6个月时,评估临床牙周参数,炎症标志物和龈下生物膜中的微生物。另外,监测RA-CP组中RA的疾病活性标记(DAS28,CRP,ESR)和特异性抗体(RF)。

结果显示,在两组中,非手术治疗可明显改善临床牙周参数,在RA患者中,在3个月时观察到血清-CRP的水平明显下降。在所有时间点,RA-CP中GCF炎症标志物的水平均高于CP患者。CP组患者牙龈卟啉单胞菌、福赛坦氏菌和齿垢密螺旋体的水平明显降低,但在RA-CP组中不明显。DAS28的变化与牙龈卟啉单胞菌的变化呈正相关,与菌斑指数呈负相关。

综上所述,该研究结果表明,(a)非手术牙周治疗可改善伴或不伴RA的CP患者的牙周状况;(b)RA患者根除牙龈卟啉菌并保持良好的口腔卫生或可暂时减少RA的疾病活动。

原始出处:

Cosgarea R, Tristiu R, et al., Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig. 2018 Mar 27. doi: 10.1007/s00784-018-2420-3.

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    2018-07-05 小几洁
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    2018-04-08 lmm397
  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
  5. 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encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303517, encodeId=27f130351e79, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 07 09:51:35 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303377, encodeId=71c23033e74b, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
    2018-04-08 liuyong2982
  6. 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encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303517, encodeId=27f130351e79, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 07 09:51:35 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303377, encodeId=71c23033e74b, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450863, encodeId=5259145086391, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, 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encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303517, encodeId=27f130351e79, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 07 09:51:35 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303377, encodeId=71c23033e74b, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
    2018-04-07 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  9. 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createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483488, encodeId=60f5148348863, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493523, encodeId=fa34149352371, content=<a href='/topic/show?id=dc4c6e51457' target=_blank style='color:#2F92EE;'>#牙周治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67514, encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Sun Apr 08 08:14:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303517, encodeId=27f130351e79, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 07 09:51:35 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303377, encodeId=71c23033e74b, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Apr 06 21:17:47 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303356, encodeId=41f5303356c5, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Fri Apr 06 19:29:28 CST 2018, time=2018-04-06, status=1, ipAttribution=)]
    2018-04-06 天地飞扬

    了解一下.谢谢分享!

    0

  10. 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    2018-04-06 wqkm

    ^_^^_^^_^^_^

    0

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